Melatonin impurity 18 CAS 515128-09-3
| CAS No. | 515128-09-3 |
| Molecular Formula | C13H16N2O4 |
| Molecular Weight | 264.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Melatonin impurity 18 (CAS 515128-09-3, C13H16N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Melatonin impurity 18 (C13H16N2O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Melatonin impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H16N2O4 |
| Molecular Weight | 264.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 2 |
Related Melatonin Standards
- Melatonin impurity 11 (CAS CATO-C4X-229211)
- Melatonin Impurity 5 (CAS 52450-38-1)
- Melatonin 2-Chloro impurity (CAS 118747-02-7)
- Melatonin 6-Chloro Impurity (CAS 63762-74-3)
- Melatonin impurity 15 (CAS 2998440-04-1)
- Melatonin impurity 7 (CAS 278783-22-5)
- Melatonin EP Impurity D (CAS 28026-16-6)
- Melatonin impurity 13 (CAS 188396-98-7)
Recommended Standards
- Roxadustat Impurity 157 (CAS CATO-C4X-2213157)
- Perampanel Impurity 23 (CAS CATO-C4X-243023)
- Hydantoin Impurity 31 (CAS 110932-42-8)
- Perampanel Impurity 7 (CAS CATO-C4X-24307)
- Semaglutide impurity 95 (CAS CATO-C4X-222695)
- Quinine Sulfate Impurity 5 (CAS 101655-92-9)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
- Pcb No. 25 (CAS 55712-37-3)
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- ((2S,4S)-4-aminopyrrolidin-2-yl)methanol (CAS 1207376-36-0)
- Tributyl aconitate (CAS 7568-58-3)
- 5-((Diethylamino)methyl)-2-methoxyaniline (CAS 857002-41-6)
- (3-Fluorotetrahydrofuran-3-yl)methanamine hydrochloride (CAS 2098093-18-4)
- Mast Cell Degranulating Peptide HR-1 (CAS 80533-94-4)
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