Methyl 4-Fluoroindole-3-acetate CAS 5159-06-8
| CAS No. | 5159-06-8 |
| Molecular Formula | C11H10FNO2 |
| Molecular Weight | 207.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 4-Fluoroindole-3-acetate (CAS 5159-06-8), molecular formula C11H10FNO2 and molecular weight 207.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl 4-Fluoroindole-3-acetate (C11H10FNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Methyl 4-Fluoroindole-3-acetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H10FNO2 |
| Molecular Weight | 207.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- Methyl 7-Fluoroindole-3-acetate (CAS 1268340-21-1)
- 5-Fluoroindole-3-acetic hydrazide (CAS 376646-57-0)
- Ethyl 5-Fluoroindole-3-carboxylate (CAS 773136-86-0)
- Ethyl 6-Fluoroindole-3-carboxylate (CAS 773136-93-9)
- Ethyl 7-Fluoroindole-2-carboxylate (CAS 348-31-2)
- Methyl 5-Fluoroindole-3-acetate (CAS 497258-29-4)
- Methyl 6-Fluoroindole-3-acetate (CAS 5159-07-9)
- 5-Fluoroindole-2-carboxylic acid ethyl ester 2-ethylformate-5-fluoro indole ethyl5-fluoro-indole-2-carboxylate 2-carbethoxy-5-fluoroindole ethyl 5-fluoro-1h-indole-2-carboxylate Ethyl 5-fluoroindole-2-carboxylate 348-36-7 (CAS 348-36-7)
Recommended Standards
- Methyl 2-cyano-3-(2-fluorophenyl)propanoate (CAS 67571-38-4)
- Methyl 5-Fluoro-2-methylindole-3-carboxylate (CAS 762288-10-8)
- Methyl 6-fluoro-2-methyl-1H-indole-3-carboxylate (CAS 762288-11-9)
- Ethyl 2-cyano-2-(3-fluorophenyl)acetate (CAS 683220-23-7)
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