Dimethyl (2-(4-fluorophenyl)-2-oxoethyl)phosphonate CAS 51638-12-1
| CAS No. | 51638-12-1 |
| Molecular Formula | C10H12FO4P |
| Molecular Weight | 246.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies Dimethyl (2-(4-fluorophenyl)-2-oxoethyl)phosphonate (CAS 51638-12-1), a certified reference material (molecular formula C10H12FO4P, MW 246.17 g/mol) for analytical method development and quality control.
The molecular framework of Dimethyl (2-(4-fluorophenyl)-2-oxoethyl)phosphonate (C10H12FO4P) is characterized by a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12FO4P |
| Molecular Weight | 246.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | F-containing |
Related Dimethyl Standards
- Dimethyl (2-(2-fluorophenyl)-2-oxoethyl)phosphonate (CAS 123587-00-8)
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- Cefixime Impurity 83 (CAS CATO-C4X-113983)
- Semaglutide impurity 58 (CAS CATO-C4X-222658)
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