2,2-Difluoro-2-(5-methoxy-1H-indol-3-yl)ethanamine hydrochloride CAS 516521-97-4
| CAS No. | 516521-97-4 |
| Molecular Formula | C11H12F2N2O |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,2-Difluoro-2-(5-methoxy-1H-indol-3-yl)ethanamine hydrochloride (CAS 516521-97-4), molecular formula C11H12F2N2OHCl and molecular weight 262.68 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 2,2-Difluoro-2-(5-methoxy-1H-indol-3-yl)ethanamine hydrochloride is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 262.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12F2N2O HCl |
| Molecular Weight | 262.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Difluoro Standards
- 2-(4,5-Difluoro-2-nitrophenyl)acetic acid (CAS 1000339-22-9)
- 1-[6,8-Difluoro-2-(trifluoromethyl)quinol-4-yl]piperazine (CAS 1000339-47-8)
- 1-[6,8-Difluoro-2-(trifluoromethyl)quinol-4-yl]homopiperazine (CAS 1000339-49-0)
- 4,7-Difluoro-1H-indazole (CAS 1000341-68-3)
- 5,7-Difluoro-2H-indazole-3-carbaldehyde (CAS 1000343-25-8)
- 6,7-Difluoro-1H-indazol-3-ol (CAS 1000343-93-0)
- 2-(3,5-Difluoro-2-pyridyl)acetic acid (CAS 1000518-01-3)
- 2-(2,4-Difluoro-3-methylphenyl)acetic acid (CAS 1000545-11-8)
Recommended Standards
- Ethyl 2-amino-4-(3-nitrophenyl)thiophene-3-carboxylate (CAS 433701-34-9)
- 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate (CAS 109028-10-6)
- 1-(difluoromethoxy)-3-isocyanatobenzene (CAS 39139-35-0)
- 1-Bromo-4-chloro-2-(trifluoromethoxy)benzene (CAS 1402672-86-9)
- 3β-Glycocholic acid, 98% (CAS 107589-98-0)
- 3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin 61899-42-1 (CAS 61899-42-1)
- (Z)-4-(1-(4-Nitrophenyl)ethylidene)-2-phenyloxazol-5(4H)-one (CAS 69015-76-5)
- 2-(Diethylamino)ethyl 3-nitro-4-propoxybenzoate (CAS 736870-51-2)
- 2-Chloro-6-(trifluoromethyl)pyridine (CAS 39890-95-4)
- Semaglutide impurity 01 (CAS 1998701-31-7)
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