(4-Chloro-2,6-difluorophenyl)methanamine CAS 518357-43-2
| CAS No. | 518357-43-2 |
| Molecular Formula | C7H6ClF2N |
| Molecular Weight | 177.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (4-Chloro-2,6-difluorophenyl)methanamine.
(4-Chloro-2,6-difluorophenyl)methanamine (CAS 518357-43-2) is a high-purity analytical reference standard with the molecular formula C7H6ClF2N and a molecular weight of 177.58 g/mol.
Based on its molecular formula C7H6ClF2N, (4-Chloro-2,6-difluorophenyl)methanamine contains a nitrile group, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 177.58 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6ClF2N |
| Molecular Weight | 177.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-4-(1,1-difluoroethyl)pyridine (CAS 1204295-63-5)
- 4-Chloro-2-(difluoromethyl)aniline (CAS 1221424-65-2)
- (3-Chloro-4,5-difluorophenyl)methanamine (CAS 1260826-45-6)
- 3-Chloro-2-(difluoromethyl)aniline (CAS 1261449-32-4)
- 2-Chloro-3-(difluoromethyl)aniline (CAS 1261499-71-1)
- 3-Chloro-5-(difluoromethyl)aniline (CAS 1261524-04-2)
- 2-Chloro-5-(difluoromethyl)aniline (CAS 1261567-27-4)
- 5-Chloro-2-(difluoromethyl)aniline (CAS 1261672-89-2)
Recommended Standards
- (3-Chloro-2,4-difluorophenyl)methanamine (CAS 886761-65-5)
- 2-Chloro-4-(difluoromethyl)aniline (CAS 202752-30-5)
- (2-Chloro-4,5-difluorophenyl)methanamine (CAS 771582-19-5)
- 2-Chloro-6-(1,1-difluoroethyl)pyridine (CAS 2551120-23-9)
- 6-Methoxy-2,3-dihydro-1H-indene-5-sulfonyl chloride (CAS 88040-92-0)
- Butyl 2-(4-formyl-2-methoxyphenoxy)acetate (CAS 1272067-50-1)
- N-(1-((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide (CAS 401812-97-3)
- (6,7-Dibromonaphthalen-2-yl)methanol (CAS 131331-20-9)
- Pyrazine-2-carboximidamide hydrochloride(1:x) (CAS 328042-01-9)
- 1-(7-Methyl-3H-pyrrolizin-6-yl)ethanone (CAS 82217-97-8)
- Azilsartan Impurity 72 (CAS 21606-04-2)
- 1,6-Naphthyridine-5,7(6H,8H)-dione (CAS 1345461-33-7)
- (E)-1-Bromo-3-methylpent-2-ene (CAS 869-72-7)
- [D-His1]-Semaglutide (CAS CATO-C4X-2226127)
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