1-((2,4-Difluorophenyl)(phenyl)methyl)piperazine CAS 518971-85-2
| CAS No. | 518971-85-2 |
| Molecular Formula | C17H18F2N2 |
| Molecular Weight | 288.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-((2,4-Difluorophenyl)(phenyl)methyl)piperazine (CAS 518971-85-2), molecular formula C17H18F2N2 and molecular weight 288.34 g/mol, is a CATO reference standard with documented purity and traceability.
1-((2,4-Difluorophenyl)(phenyl)methyl)piperazine (C17H18F2N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18F2N2 |
| Molecular Weight | 288.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluorophenyl Standards
- (3,4-Difluorophenyl)(4-pentylphenyl)methanone (CAS 951887-65-3)
- (3,5-Difluorophenyl)(4-pentylphenyl)methanone (CAS 951887-69-7)
- 1-(2,6-Difluorophenyl)-1,3-Dihydro-[1,3]Thiazolo[3,4-a]Benzimidazole (CAS 138226-12-7)
- (1S)-1-(2,6-Difluorophenyl)-1,3-Dihydro-[1,3]Thiazolo[3,4-a]Benzimidazole (CAS 194161-14-3)
- (E)-4-(3-(2,4-Difluorophenyl)-3-oxoprop-1-en-1-yl)benzoic acid (CAS 2651958-69-7)
- (E)-4-(3-(2,5-Difluorophenyl)-3-oxoprop-1-en-1-yl)benzoic acid (CAS 2651958-68-6)
- 1-(2,4-Difluorophenyl)-2-methyl-1H-benzimidazole-5-carboxylic acid (CAS 442531-48-8)
- 1-(2,4-Difluorophenyl)-5-(4-methoxyphenyl)-1H-tetrazole (CAS 339108-68-8)
Recommended Standards
- [1,1'-Biphenyl]-4-yl(3-methoxyphenyl)methanone (CAS 79447-10-2)
- 1-([1,1'-Biphenyl]-4-yl)-2-phenoxyethan-1-one (CAS 29263-70-5)
- (Z)-3-(2,5-dimethoxyanilino)-2-(2,2-dimethylpropanoyl)-2-propenenitrile (CAS 208348-00-9)
- 1-(1H-Indol-3-yl)-3-(2-morpholinoethyl)urea (CAS 899965-04-9)
- Hexazinone metabolite F (CAS 56611-55-3)
- (R)-2-(2-Bromophenyl)-4-methyl-4,5-dihydrooxazole (CAS 339316-16-4)
- 2-(Difluoromethyl)-3-iodo-4-nitropyridine-6-acetic acid (CAS 1807096-27-0)
- 2-(4-Methoxyphenyl)-5-(4-octylphenyl)-1,3,4-oxadiazole (CAS 821782-01-8)
- Ethyl 4-(4-ethoxyphenyl)thiazole-2-carboxylate (CAS 886366-48-9)
- (2-Bromo-6-fluoro-3-nitrophenyl)methanamine (CAS 1805177-00-7)
- 6-(Piperazin-1-yl)pyridazine-4-carboxylic acid (CAS 1706442-50-3)
- 2-(4,6-Dichloro-2-cyclopropylpyrimidin-5-yl)acetaldehyde (CAS 1311275-29-2)
- 5-(3-Cyanophenyl)nicotinic acid (CAS 893740-73-3)
- Semaglutide Impurity 12 (CAS CATO-C4X-222612)
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