Methyl Iodoacetate CAS 5199-50-8
| CAS No. | 5199-50-8 |
| Molecular Formula | C3H5IO2 |
| Molecular Weight | 199.98 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methyl Iodoacetate is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Methyl Iodoacetate (CAS 5199-50-8), molecular formula C3H5IO2 and molecular weight 199.98 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl Iodoacetate (C3H5IO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl Iodoacetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C3H5IO2 |
| Molecular Weight | 199.98 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | I-containing |
Related Methyl Standards
- 623-48-3 Ethyl iodoacetate Acetic acid, iodo-, ethyl ester Acetic acid, 2-iodo-, ethyl ester S 9 4-02-00-00535 (Beilstein Handbook Reference) BRN 0741934 EINECS 210-796-3 Ethyl monoiodoacetate Ethylester kyseliny jodoctove [Czech] Iodoacetic acid, ethyl ester NSC 58809 Ethylester kyseliny jodoctove (CAS 623-48-3)
- Butyl 2-iodoacetate (CAS 5345-61-9)
- Benzyl 2-iodoacetate (CAS 81867-37-0)
- Sodium iodoacetate (CAS 305-53-3)
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