4-chlorothiazol-2-amine CAS 52107-46-7

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-chlorothiazol-2-amine.

4-chlorothiazol-2-amine (CAS 52107-46-7) is a high-purity analytical reference standard with the molecular formula C3H7ClN2S and a molecular weight of 138.62 g/mol.

Owing to sulfur-containing functionality, chlorine substitution, 4-chlorothiazol-2-amine is typically white to off-white liquid. Its solid-state physicochemical attributes — including a molecular weight of 138.62 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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