4-(Trifluoromethyl)benzene-1-sulfonyl fluoride CAS 52201-01-1
| CAS No. | 52201-01-1 |
| Molecular Formula | C7H4F4O2S |
| Molecular Weight | 228.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4-(Trifluoromethyl)benzene-1-sulfonyl fluoride (CAS 52201-01-1), molecular formula C7H4F4O2S and molecular weight 228.16 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Trifluoromethyl)benzene-1-sulfonyl fluoride (C7H4F4O2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4F4O2S |
| Molecular Weight | 228.16 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Trifluoromethyl Standards
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- 3-(6-(Trifluoromethyl)pyridin-3-yl)-1H-pyrazol-5-amine (CAS 1040724-49-9)
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- 2-Methyl-8-(trifluoromethyl)quinazolin-4(3H)-one (CAS 1112985-71-3)
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Recommended Standards
- 3-[(5-nitrofuran-2-yl)formamido]propanoic acid (CAS 746608-27-5)
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- 4,4,5,5-tetramethyl-2-(4-methylthiophen-2-yl)-1,3,2-dioxaborolane (CAS 635305-48-5)
- 2,6-Dimethoxy-5-nitronicotinic acid (CAS 685879-38-3)
- 6-Amino-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide (CAS 88796-49-0)
- 5-(2-Fluorophenyl)-6-(trifluoromethyl)pyridine-2-thiol (CAS 1214333-23-9)
- 3-Hydroxy-1-phenyl-1H-pyrazole-5-carboxylic acid (CAS 3950-18-3)
- Coumestrol (CAS 479-13-0)
- (2-Isocyanatoethane-1,1-diyl)dibenzene (CAS 58749-50-1)
- Methyl 3-fluoro-4-isopropoxybenzoate (CAS 1346498-59-6)
- 1-(3-(Trifluoromethyl)benzyl)imidazolidine-2,4,5-trione (CAS 339104-08-4)
- 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine (CAS 297172-18-0)
- 3-(5-(tert-Butyl)furan-2-yl)-6-iodoisobenzofuran-1(3H)-one (CAS 888498-14-4)
- Liraglutide(13-31)TFA Salt (CAS CATO-C4X-19929)
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