4'-Nitroacetophenone semicarbazone CAS 52376-81-5
| CAS No. | 52376-81-5 |
| Molecular Formula | C9H10N4O3 |
| Molecular Weight | 222.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 222.20 g/mol gives 4'-Nitroacetophenone semicarbazone distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4'-Nitroacetophenone semicarbazone (CAS 52376-81-5), molecular formula C9H10N4O3 and molecular weight 222.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4'-Nitroacetophenone semicarbazone (C9H10N4O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4'-Nitroacetophenone semicarbazone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H10N4O3 |
| Molecular Weight | 222.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Nitrogen Atoms | 4 |
Related Nitroacetophenone Standards
Recommended Standards
- 4-Carbamoyl-3,4-dihydro-2h-benzo[b][1,4]oxazine-2-carboxylic acid (CAS 953899-84-8)
- 4-Nitrophenyl cyclopropylcarbamate (CAS 444288-42-0)
- 4,6-Dimethoxy-1H-indazole-3-carboxylic acid (CAS 885520-36-5)
- 5-((3-Amino-1H-1,2,4-triazol-1-yl)methyl)furan-2-carbohydrazide (CAS 381201-04-3)
- 4-Bromo-5-(trifluoromethoxy)-1,2-phenylenediamine (CAS 156425-07-9)
- 6-Amino-2-methylbenzimidazole (CAS 29043-48-9)
- 5-Iodo-2-bromo-4-methoxyphenol (CAS 186134-38-3)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)benzaldehyde (CAS 1422268-45-8)
- Tert-butyl decahydro-4H-benzo[e][1,4]diazepine-4-carboxylate (CAS 1369133-31-2)
- 4-Methyl-2,3-dihydro-1H-inden-1-ol (CAS 67864-03-3)
- N-(6-bromopyridin-2-yl)pivalamide (CAS 221087-47-4)
- 5-[(4-chloro-3-nitro-1h-pyrazol-1-yl)methyl]furan-2-carbaldehyde (CAS 512809-42-6)
- 3,4-Diiodo-1H-pyrrole-2,5-dione (CAS 51650-29-4)
- Des-Gly34-Tirzepatide (CAS CATO-CPTD788940)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com