1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carbonyl chloride CAS 52377-28-3
| CAS No. | 52377-28-3 |
| Molecular Formula | C12H11ClN2O2 |
| Molecular Weight | 250.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carbonyl chloride.
CATO supplies 1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carbonyl chloride (CAS 52377-28-3), a certified reference material (molecular formula C12H11ClN2O2, MW 250.68 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carbonyl chloride is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 250.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carbonyl chloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H11ClN2O2 |
| Molecular Weight | 250.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- 1-Benzyl-5-chloro-3-methyl-1h-pyrazole-4-carboxylic acid (CAS 882227-05-6)
- 2-(2-(4-Chlorophenyl)-5-oxocyclopent-1-en-1-yl)acetic acid (CAS 53272-87-0)
- 1-(5-Chloro-1-methyl-1H-pyrazol-4-yl)-3-phenylurea (CAS 648427-15-0)
- 2-(3-Chlorophenyl)-4-((dimethylamino)methylene)oxazol-5(4H)-one (CAS 373618-95-2)
- 4,4-dimethoxybutanoic acid (CAS 35848-90-9)
- Methyl 5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate (CAS 401620-84-6)
- 1-(5-Oxo-1-(p-tolyl)pyrrolidine-3-carbonyl)piperidine-4-carboxylic acid (CAS 1010929-78-8)
- 6-Bromo-5-chloro-2,3-dihydrobenzofuran (CAS 1345120-17-3)
- N-(3,5-Dimethylphenyl)-2-(dodecylsulfanyl)acetamide (CAS 331461-50-8)
- (3S,6R)-1-(tert-butoxycarbonyl)-6-methylpiperidine-3-carboxylic acid (CAS 1253200-92-8)
- 3-(Isopropoxymethyl)phenylboronic Acid (CAS 1333122-39-6)
- Lenvatinib Impurity 139 (CAS CATO-C4X-1140139)
- 2-Ethoxy-N-(4-((6-methoxyquinolin-8-yl)amino)pentyl)acetamide (CAS 105234-63-7)
- Semaglutide impurity 108 (CAS CATO-C4X-2226108)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com