N-Hydroxy-1,2-benzisoxazole-3-acetamide CAS 52385-92-9
| CAS No. | 52385-92-9 |
| Molecular Formula | C9H8N2O3 |
| Molecular Weight | 192.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-Hydroxy-1,2-benzisoxazole-3-acetamide (CAS 52385-92-9) is a high-purity analytical reference standard with the molecular formula C9H8N2O3 and a molecular weight of 192.17 g/mol.
The molecular framework of N-Hydroxy-1,2-benzisoxazole-3-acetamide (C9H8N2O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-Hydroxy-1,2-benzisoxazole-3-acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8N2O3 |
| Molecular Weight | 192.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Nitrogen Atoms | 2 |
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Recommended Standards
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- Ethyl 6-bromo-3-chloro-5-methylpyrazine-2-carboxylate (CAS 2091009-80-0)
- Ethyl 2-amino-5-{[(4-chlorophenyl)amino]carbonyl}-4-methylthiophene-3-carboxylate (CAS 5655-15-2)
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- Tetradecyl 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-b-D-glucopyranoside (CAS 173725-25-2)
- 2-Bromo-1-(2,6-difluoro-3-nitrophenyl)ethanone (CAS 746630-00-2)
- {2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl}boronic acid (CAS 2304634-03-3)
- 2-(4-Chlorobenzyl)quinuclidin-3-one (CAS 112628-51-0)
- Faropenem Impurity 22 (CAS CATO-C4X-128922)
- Semaglutide impurity 251 (CAS CATO-C4X-2226251)
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