N-(5-bromopyridin-2-yl)-3-fluorobenzamide CAS 5246-16-2
| CAS No. | 5246-16-2 |
| Molecular Formula | C12H8BrFN2O |
| Molecular Weight | 295.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(5-bromopyridin-2-yl)-3-fluorobenzamide (CAS 5246-16-2), molecular formula C12H8BrFN2O and molecular weight 295.11 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(5-bromopyridin-2-yl)-3-fluorobenzamide (C12H8BrFN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8BrFN2O |
| Molecular Weight | 295.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-(5-bromopyridin-2-yl)-4-fluorobenzamide (CAS 300717-33-3)
- 1-(5-Bromopyridin-2-yl)-2,5-dimethyl-1h-pyrrole-3-carboxylic acid (CAS 1152547-68-6)
- 2-((5-Bromopyridin-3-yl)oxy)-3-ethoxypyridine (CAS 1912227-02-1)
- 2-((5-Bromopyridin-3-yl)oxy)-3-nitropyridine (CAS 1355666-55-5)
- 5-[(5-bromopyridin-3-yl)oxy]pyrazine-2-carboxylic acid (CAS 1378725-84-8)
- 2-(2-Bromopyridin-4-yl)-1-(4-fluorophenyl)ethan-1-one (CAS 158876-70-1)
- 5-(((2-Bromopyridin-3-yl)oxy)methyl)-3-cyclopropyl-1,2,4-oxadiazole (CAS 1375188-85-4)
- 4-[(5-bromopyridin-2-yl)oxy]benzoic acid (CAS 58835-85-1)
Recommended Standards
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- N-(2-Bromo-4-nitrophenyl)methanesulfonamide (CAS 51765-50-5)
- 2-(2,5-Dichlorobenzoyl)benzoic acid (CAS 106022-00-8)
- Methyl 2-amino-4-fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (CAS 2415255-59-1)
- 5-Hydroxypentanal (CAS 4221-03-8)
- 1,1,1-Trichloro-3-(quinolin-2-yl)propan-2-ol (CAS 56211-74-6)
- 6-Chloro-2-oxoindoline-3-carbaldehyde (CAS 52508-91-5)
- 4-(5-(Hydroxymethyl)-4-methylpyridin-2-yl)piperazine-1-carbaldehyde (CAS 1355229-16-1)
- 2-(4-Ethoxyphenyl)thiazolidine (CAS 937602-47-6)
- 8-Oxaspiro[4.5]decan-1-one (CAS 1380389-10-5)
- 2,5-Diiodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1227270-95-2)
- 2-Chloro-6-methyl-1,5-naphthyridine (CAS 764717-61-5)
- 56632-37-2 AR-1I0068 bis(2-chloroethyl) 2,2-dichloroethenyl phosphate (CAS 56632-37-2)
- Fragment-[7-31]-Liraglutide (CAS CATO-C4X-199239)
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