4-Chloro-5-fluoroquinazoline hydrochloride CAS 524955-72-4
| CAS No. | 524955-72-4 |
| Molecular Formula | C8H4ClFN2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-5-fluoroquinazoline hydrochloride (CAS 524955-72-4) is a high-purity analytical reference standard with the molecular formula C8H4ClFN2HCl and a molecular weight of 219.04 g/mol.
The molecular framework of 4-Chloro-5-fluoroquinazoline hydrochloride (C8H4ClFN2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4ClFN2 HCl |
| Molecular Weight | 219.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- Tert-butyl (S)-4-methyl-2,5-dioxooxazolidine-3-carboxylate (CAS 125814-30-4)
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- 4-Amino-5,8-difluoroquinoline-3-carbohydrazide (CAS 1315350-14-1)
- Azido-PEG24-NHS ester (CAS 2375600-46-5)
- 7-Chloro-2-mercapto-3-propylquinazolin-4(3h)-one (CAS 733031-01-1)
- N-(4-Ethynylphenyl)cyclohexanecarboxamide (CAS 118984-62-6)
- 1-(3,4-dichlorophenyl)-6-hydroxy-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (CAS 340216-43-5)
- 4-(4-Chlorophenyl)-2-methyl-3-butyn-2-ol (CAS 75373-70-5)
- Methyl 3-hydroxy-5-methyl-1H-indole-2-carboxylate (CAS 113525-13-6)
- [y-Glu15]-Semaglutide Impurity 134 (CAS CATO-C4X-2226134)
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