4,6-Dichloropyrimidine-5-carbaldehyde CAS 5305-40-8
| CAS No. | 5305-40-8 |
| Molecular Formula | C5H2Cl2N2O |
| Molecular Weight | 176.99 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4,6-Dichloropyrimidine-5-carbaldehyde (CAS 5305-40-8), molecular formula C5H2Cl2N2O and molecular weight 176.99 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4,6-Dichloropyrimidine-5-carbaldehyde (C5H2Cl2N2O) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,6-Dichloropyrimidine-5-carbaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H2Cl2N2O |
| Molecular Weight | 176.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichloropyrimidine Standards
- 2,5-Dichloropyrimidine-4-carbaldehyde (CAS 1803728-57-5)
- 4,5-Dichloropyrimidine-2-carbaldehyde (CAS 1803849-33-3)
- 5,6-Dichloropyrimidine-4-carbaldehyde (CAS 1806317-35-0)
- 2,4-Dichloropyrimidine-5-carbaldehyde (CAS 871254-61-4)
- 2,6-Dichloropyrimidine-4-carbaldehyde (CAS 933746-24-8)
- 4,6-Dichloropyrimidine-2-carbaldehyde (CAS 684220-28-8)
- 4,6-dichloropyrimidine-2,5-diamine (CAS 55583-59-0)
- 2,5-Dichloropyrimidine-4-carbonitrile (CAS 1804892-77-0)
Recommended Standards
- 6-Chloropyridazine-3-carbonyl chloride (CAS 6531-04-0)
- 3-Chloropyrazine-2-carbonyl chloride (CAS 90361-99-2)
- 6-Chloropyrimidine-4-carbonyl chloride (CAS 263270-52-6)
- 286013-10-3 Benzyl bromide-(ring-13C6) |A-Bromotoluene-(phenyl-13C6) (CAS 286013-10-3)
- 6-Methyl-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-ol (CAS 344776-71-2)
- N-(2-(2-((Dipropylamino)methyl)piperidin-1-yl)ethyl)-6-oxo-5H-benzo[e]pyrido[3,2-b][1,4]diazepine-11(6H)-carboxamide (CAS 118290-26-9)
- 1-(4-(1-Aminoethyl)piperidin-1-yl)ethan-1-one (CAS 1268522-23-1)
- 7-Hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carbohydrazide (CAS 378205-41-5)
- 2-(((1-Benzylpiperidin-3-yl)methyl)(methyl)amino)ethanol (CAS 1353986-14-7)
- 3,3,3-Trifluoro-<SC>DL</SC>-alanine (CAS 17463-43-3)
- 4-(4-Bromo-3-methylphenyl)oxazolidin-2-one (CAS 1519517-20-4)
- (4-(Aminomethyl)piperidin-1-yl)(pyridin-3-yl)methanone (CAS 1018258-85-9)
- 3,6-Difluoro-2-iodobenzoic acid (CAS 501432-98-0)
- Liraglutide Impurity 13 TFA Salt (CAS CATO-C4X-199213)
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