(1E,4E)-1,5-Bis(4-fluorophenyl)-1,4-pentadien-3-one CAS 53369-00-9

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (1E,4E)-1,5-Bis(4-fluorophenyl)-1,4-pentadien-3-one.

(1E,4E)-1,5-Bis(4-fluorophenyl)-1,4-pentadien-3-one (CAS 53369-00-9), molecular formula C17H12F2O and molecular weight 270.27 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of (1E,4E)-1,5-Bis(4-fluorophenyl)-1,4-pentadien-3-one (C17H12F2O) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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