Proguanil EP Impurity F CAS 537-21-3
| CAS No. | 537-21-3 |
| Molecular Formula | C11H15Cl2N5 |
| Molecular Weight | 288.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Proguanil EP Impurity F (CAS 537-21-3, C11H15Cl2N5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Proguanil EP Impurity F is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 288.18 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H15Cl2N5 |
| Molecular Weight | 288.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Proguanil Standards
- Proguanil impurity 1 (CAS CATO-C4X-17391)
- Proguanil (CAS 500-92-5)
- Proguanil EP Impurity G (CAS 807308-41-4)
- Proguanil EP Impurity E (CAS 1482-62-8)
- Proguanil EP Impurity D (CAS 45095-69-0)
- Proguanil EP Impurity A (CAS 44830-55-9)
- Proguanil EP Impurity G Hydrochloride (CAS 1071546-52-5)
- Proguanil EP Impurity C (CAS 13590-88-0)
Recommended Standards
- N-(5-bromo-2-methoxybenzyl)-3-methoxypropan-1-amine (CAS 932241-22-0)
- Perospirone Impurity 37 (CAS 164519-76-0)
- Amino(3-bromo-1-adamantyl)acetic acid (CAS 345969-40-6)
- Perospirone Impurity 51 (CAS CATO-C4X-245851)
- All-Rac-Α-Tocopheryl Acetate EP Impurity B (CAS CATO-C4X-177916)
- Metaraminol impound 105 (CAS CATO-C4X-2252105)
- Ketoprofen impurity 75 (CAS 319482-67-2)
- 1-Allyl-3-bromo-5-fluorobenzene (CAS 868860-65-5)
- 1-Chloroisoquinoline-3-carboxylic acid (CAS 1049606-80-5)
- n-Cyclopropyl-2-(piperidin-4-yloxy)acetamide (CAS 912761-41-2)
- 2-Deoxy-D-ribose-5- (CAS 159838-86-5)
- 2-(4-Bromophenyl)-5-ethyl-5-methylmorpholine (CAS 1343613-93-3)
- (4,5-Dimethoxy-1H-indol-2-yl)methanol (CAS 1383924-67-1)
- Peptide Impurity (CAS CATO-CPTD788810)
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