3-(1,3,4-Oxadiazol-2-yl)phenol CAS 5378-29-0
| CAS No. | 5378-29-0 |
| Molecular Formula | C8H6N2O2 |
| Molecular Weight | 162.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
3-(1,3,4-Oxadiazol-2-yl)phenol (CAS 5378-29-0) is a high-purity analytical reference standard with the molecular formula C8H6N2O2 and a molecular weight of 162.15 g/mol.
The molecular framework of 3-(1,3,4-Oxadiazol-2-yl)phenol (C8H6N2O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6N2O2 |
| Molecular Weight | 162.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Oxadiazol Standards
- 3-Phenyl-1,2,3-oxadiazol-3-ium-5-olate (CAS 120-06-9)
- 2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrazine (CAS 1283108-90-6)
- 3-Phenyl-1,2,4-oxadiazol-5-ol (CAS 1456-22-0)
- 4-(1,3,4-Oxadiazol-2-yl)phenol (CAS 5378-27-8)
- 5-(1,3,4-oxadiazol-2-yl)-1,2-dihydropyridin-2-one (CAS 1146290-37-0)
- 4-phenyl-1,2,5-oxadiazol-3-amine (CAS 10349-14-1)
- 2-(3-Methyl-1,2,4-oxadiazol-5-yl)pyridine (CAS 1455-84-1)
- 3-(3-Methyl-1,2,4-oxadiazol-5-yl)pyridine (CAS 1455-85-2)
Recommended Standards
- 2-Oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carbaldehyde (CAS 313500-60-6)
- 3-(1H-Tetrazol-5-yl)phenol (CAS 96859-34-6)
- 2-Methylpyrido[4,3-d][1,3]oxazin-4-one (CAS 3810-23-9)
- 3-(Furan-2-yl)-1H-pyrazole-4-carbaldehyde (CAS 61619-81-6)
- N-Desmethylflunitrazepam-D4 (CAS 1397234-19-3)
- 2-Ethyl-4-(4-methylpiperidin-1-yl)benzofuro[3,2-d]pyrimidine hydrochloride (CAS 1052520-42-9)
- Benzyl o-tolylcarbamate (CAS 108714-89-2)
- 1-(3-Methoxybenzyl)guanidine (CAS 46228-51-7)
- 1-(Bromomethyl)-1-cyclohexene (CAS 37677-17-1)
- 2-Fluoro-5-(imidazo[2,1-b]thiazol-6-yl)aniline (CAS 1283109-57-8)
- Levocetirizine Impurity 79 (CAS CATO-C4X-108379)
- 2-Methyl-2-propenyl Acetate (CAS 820-71-3)
- 2-Iodopyrimidine-5-carbonitrile (CAS 1805492-68-5)
- Peptide 441 (CAS CATO-CPTD788441)
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