1-(4-Chlorophenyl)-3-(3-(difluoromethoxy)phenyl)urea CAS 540771-25-3
| CAS No. | 540771-25-3 |
| Molecular Formula | C14H11ClF2N2O2 |
| Molecular Weight | 312.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(4-Chlorophenyl)-3-(3-(difluoromethoxy)phenyl)urea (C14H11ClF2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
1-(4-Chlorophenyl)-3-(3-(difluoromethoxy)phenyl)urea (CAS 540771-25-3) is a high-purity analytical reference standard with the molecular formula C14H11ClF2N2O2 and a molecular weight of 312.70 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11ClF2N2O2 |
| Molecular Weight | 312.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorophenyl Standards
- 1-(4-Chlorophenyl)-3-(3-(difluoromethoxy)phenyl)urea (CAS 886542-48-9)
- 3-(4-Chlorophenyl)benzofuro[3,2-d]pyrimidine-2,4(1H,3H)-dione (CAS 121997-02-2)
- 5-(2-(3-Chlorophenyl)benzo[d]oxazol-5-yl)-1,3,4-oxadiazol-2-amine (CAS 1706449-46-8)
- 5-(2-(2-Chlorophenyl)benzo[d]oxazol-5-yl)-1,3,4-oxadiazol-2-amine (CAS 1706449-61-7)
- 3-(3-Chlorophenyl)-1-(2-(trifluoromethyl)phenyl)propan-1-one (CAS 898787-26-3)
- 3-(3-Chlorophenyl)-1-(3-(trifluoromethyl)phenyl)propan-1-one (CAS 898787-28-5)
- 3-(3-Chlorophenyl)-1-(4-(trifluoromethyl)phenyl)propan-1-one (CAS 898787-30-9)
- 3-(4-Chlorophenyl)-1-(4-(trifluoromethyl)phenyl)propan-1-one (CAS 898788-29-9)
Recommended Standards
- (E)-N'-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)carbamothioyl)-N-hydroxy-N-methylformimidamide (CAS 477885-62-4)
- 4-Amino-2-chloro-N-(2-(difluoromethoxy)phenyl)benzamide (CAS 1096935-52-2)
- Benzyl 3-chloro-4-(difluoromethoxy)benzoate (CAS 2364584-74-5)
- 5-Amino-2-chloro-N-(2-(difluoromethoxy)phenyl)benzamide (CAS 1094218-45-7)
- Methyl 2-(4-Chloro-3-cyanophenyl)acetate (CAS 1261572-64-8)
- Ethyl 4-(1H-purin-6-yl)piperazine-1-carboxylate (CAS 84806-94-0)
- 2-Acetamido-5-naphthol-7-sulfonicacid (CAS 6334-97-0)
- 4-(5-(4-Chlorophenyl)-1H-1,2,4-triazol-3-yl)piperidine (CAS 1205747-38-1)
- 8-(Trifluoromethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (CAS 19735-44-5)
- (s)-2-(1-Amino-2-hydroxyethyl)-3-chlorophenol (CAS 1213055-70-9)
- 2-((2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yl)oxy)acetic acid (CAS 112858-85-2)
- 4-(4-(Allyloxy)benzoyl)-5-(3-fluorophenyl)-3-hydroxy-1-(2-methoxyethyl)-1H-pyrrol-2(5H)-one (CAS 618077-34-2)
- 6-Chloroimidazo[1,2-a]pyridine hydrochloride (CAS 957035-24-4)
- Tau Peptide (294-305) (human) trifluoroacetate salt (CAS 1428135-29-8)
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