4-Chlorophenylphosphonic acid CAS 5431-35-6
| CAS No. | 5431-35-6 |
| Molecular Formula | C6H6ClO3P |
| Molecular Weight | 192.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 192.54 g/mol gives 4-Chlorophenylphosphonic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Chlorophenylphosphonic acid (CAS 5431-35-6), molecular formula C6H6ClO3P and molecular weight 192.54 g/mol, is a CATO reference standard with documented purity and traceability.
4-Chlorophenylphosphonic acid (C6H6ClO3P) contains a phosphonate group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chlorophenylphosphonic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6ClO3P |
| Molecular Weight | 192.54 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Recommended Standards
- (3-Chlorophenyl)phosphonic acid (CAS 5431-34-5)
- 2-Chloro-4,5-difluorobenzoic acid (CAS 110877-64-0)
- 5-Chloro-2,4,6-trifluoronicotinonitrile (CAS 24488-20-8)
- 4-Chloro-3,5-difluorobenzoic Acid (CAS 1160573-19-2)
- Dimethyl ((2S,2'S)-((2S,2'S,3aS,3a'S,7aS,7a'S)-(1,4(1,4)-dibenzenacyclohexaphane-12,43-diylbis(1H-benzo[d]imidazole-6,2-diyl))bis(octahydro-1H-indole-2,1-diyl))bis(3-methyl-1-oxobutane-1,2-diyl))dicarbamate (CAS 1415119-52-6)
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- 2,2,2-Trifluoroethyl n-[2-(4-methoxyphenoxy)pyridin-3-yl]carbamate (CAS 1221725-36-5)
- alpha-Vinylbenzyl Alcohol (CAS 4393-06-0)
- 3-chloro-5-methoxy-benzenethiol (CAS 779198-52-6)
- N-(2-Chloroethyl)-1-(4-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide (CAS 899960-00-0)
- 2-(Chloromethyl)-5-(methylsulfonyl)pyridine (CAS 1196151-88-8)
- 4'-Bromo-2'-fluorobiphenyl-4-sulfonyl chloride (CAS 36627-43-7)
- Ethyl 2-((4-isopropylphenyl)amino)-2-oxoacetate (CAS 349085-40-1)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
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