4-Amino-2-chloro-6-methyl-5-nitropyrimidine CAS 5453-06-5
| CAS No. | 5453-06-5 |
| Molecular Formula | C5H5ClN4O2 |
| Molecular Weight | 188.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 4-Amino-2-chloro-6-methyl-5-nitropyrimidine (CAS 5453-06-5), a certified reference material (molecular formula C5H5ClN4O2, MW 188.57 g/mol) for analytical method development and quality control.
The molecular framework of 4-Amino-2-chloro-6-methyl-5-nitropyrimidine (C5H5ClN4O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H5ClN4O2 |
| Molecular Weight | 188.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Amino Standards
- 2-Amino-4-chloro-6-methyl-5-nitropyrimidine (CAS 13162-24-8)
- 2-Amino-4-chloro-5-nitrophenol (CAS 6358-07-2)
- 2-Amino-4-chloro-6-nitrophenol (CAS 6358-08-3)
- 2-Amino-5-chloro-3-nitrophenol (CAS 924274-94-2)
- 2-Amino-5-chloro-4-nitrophenol (CAS 78827-35-7)
- 4-Amino-2-chloro-6-nitrophenol (CAS 56962-02-8)
- 5-AMino-4-chloro-2-nitrophenol (CAS 2055119-04-3)
- 2-Amino-6-chloro-4-nitrophenol (CAS 6358-09-4)
Recommended Standards
- 3-Chloro-5-methyl-4-nitropyridine 1-oxide (CAS 97944-37-1)
- 3-Chloro-4-hydrazinyl-5-nitropyridine (CAS 90927-90-5)
- 4-Chloro-1-methyl-3-nitropyridin-2(1H)-one (CAS 719268-89-0)
- 3-Chloro-4,5-dihydroxybenzoic acid (CAS 87932-49-8)
- 2,5-Dimethylfuro[2,3-d]pyrimidin-4-amine (CAS 1369247-36-8)
- (S)-Hexahydro-1H-pyrrolo[2,1-d][1,2,5]triazepine-1,5(2H)-dione (CAS 175853-35-7)
- N-(4-(4-Ethylpiperazin-1-yl)phenyl)quinolin-4-amine (CAS 313494-81-4)
- 3-Bromo-5-chloro-2-fluorobenzyl alcohol (CAS 1809161-65-6)
- 5-Hydroxy-2,3-dimethoxybenzoic acid (CAS 116530-57-5)
- 131747-70-1 2-Cyanopyridine-4-carboxaldehyde 4-Formylpyridine-2-carbonitrile;2-Pyridinecarbonitrile,4-formyl-(9CI);4-Formylpicolinonitrile A25812 (CAS 131747-70-1)
- 4-(3-Hydroxypyrrolidin-1-yl)benzonitrile (CAS 536742-59-3)
- 2,6-Diazaspiro[3.4]octan-8-one, 2-(2,2,2-trifluoroacetyl)-, 8-(O-methyloxime), (8Z)-, methanesulfonate (1:1) (CAS 1825361-14-5)
- 1-(1H-Indol-3-yl)-2-(triphenylphosphoranylidene)ethanone (CAS 91543-07-6)
- Semaglutide impurity 211 (CAS CATO-C4X-2226211)
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