Methylergometrine Impurity 1 CAS 5516-91-6
| CAS No. | 5516-91-6 |
| Molecular Formula | C20H25N3O2 |
| Molecular Weight | 339.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methylergometrine Impurity 1 (C20H25N3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Methylergometrine Impurity 1 (CAS 5516-91-6, C20H25N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H25N3O2 |
| Molecular Weight | 339.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 3 |
Related Methylergometrine Standards
- Methylergometrine (CAS 113-42-8)
- Methylergometrine EP Impurity G (CAS 5793-04-4)
- Methylergometrine Impurity 6 (CAS CATO-C4X-19486)
- Methylergometrine Impurity 7 (CAS CATO-C4X-19487)
- Methylergometrine EP Impurity C (CAS 478-94-4)
- Methylergometrine Impurity 13 (CAS 569-26-6)
- Methylergometrine EP Impurity I Acetate (CAS 724767-21-9 (free base))
Recommended Standards
- Lidocaine EP Impurity E (CAS 745798-07-6)
- Methylergonovine Enantiomer (CAS CATO-C4X-194810)
- Gabapentin Impurity 24 (CAS CATO-C4X-165424)
- Ergometrine Maleate EP Impurity H (CAS 29477-88-1)
- Vardenafil Impurity 33 (CAS CATO-C4X-101733)
- Safinamide Impurity 56 (CAS CATO-C4X-159056)
- Peramivir Impurity 78 (CAS CATO-C4X-183378)
- (2S,4R)-2-(Trifluoromethyl)piperidin-4-ol hydrochloride (CAS 2387573-36-4)
- methyl 4-aminothieno[3,2-c]pyridine-7-carboxylate (CAS 2092800-09-2)
- tert-Butyl N-[3-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate (CAS 1352413-09-2)
- Tert-butyl 2-formyl-1-methyl-1H-imidazole-5-carboxylate (CAS 293733-40-1)
- Ethyl 2-((1-bromonaphthalen-2-yl)oxy)acetate (CAS 41791-60-0)
- 2,2-Dithiobis(thiazole) (CAS 20362-54-3)
- Neuropeptide S (rat) (CAS 412938-75-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com