2-(2-Ethoxy-4-formyl-6-iodophenoxy)-N-(p-tolyl)acetamide CAS 553630-09-4
| CAS No. | 553630-09-4 |
| Molecular Formula | C18H18INO4 |
| Molecular Weight | 439.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(2-Ethoxy-4-formyl-6-iodophenoxy)-N-(p-tolyl)acetamide.
2-(2-Ethoxy-4-formyl-6-iodophenoxy)-N-(p-tolyl)acetamide (CAS 553630-09-4), molecular formula C18H18INO4 and molecular weight 439.24 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(2-Ethoxy-4-formyl-6-iodophenoxy)-N-(p-tolyl)acetamide (C18H18INO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18INO4 |
| Molecular Weight | 439.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Ethoxy Standards
- 2-(2-Ethoxy-4-formyl-6-iodophenoxy)-N-(m-tolyl)acetamide (CAS 552852-36-5)
- 4-(4-Ethoxy-3-methylbenzoyl)-1-(3-ethoxypropyl)-3-hydroxy-5-(p-tolyl)-1H-pyrrol-2(5H)-one (CAS 617694-22-1)
- 4-Ethoxy-n-{2-[2-methyl-5-(trifluoromethoxy)-1h-indol-3-yl]ethyl}benzene-1-sulfonamide (CAS 681844-04-2)
- 2-(3-Ethoxy-4-propoxybenzylidene)-6-phenyl-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione (CAS 617694-37-8)
- 2-((6-Ethoxy-2-phenylquinazolin-4-yl)thio)-N-(2-ethylphenyl)acetamide (CAS 333330-83-9)
- (E)-3-(4-ethoxy-3,5-diiodophenyl)acrylic acid (CAS 938018-89-4)
- Ethyl 3-ethoxy-4-((2-fluorobenzyl)oxy)-5-iodobenzoate (CAS 1706450-58-9)
- Ethyl 3-ethoxy-4-((4-fluorobenzyl)oxy)-5-iodobenzoate (CAS 1706452-00-7)
Recommended Standards
- N-Benzyl-1,1,2,2,3,3,4,4,5,5,5-Undecafluoro-Pentane-1-Sulfonamide (CAS 68298-08-8)
- (2E)-N-(4-Iodophenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-enamide (CAS 329778-49-6)
- N-benzyl-2-(2-ethoxy-4-formyl-6-iodophenoxy)acetamide (CAS 486994-15-4)
- Ethyl 6-bromo-4-((3-(trifluoromethyl)phenyl)amino)quinoline-3-carboxylate (CAS 449197-54-0)
- Methyl 6-(tert-butylamino)nicotinate (CAS 1355204-42-0)
- Ethyl 3-hydroxytetrahydro-2H-pyran-4-carboxylate (CAS 2091548-14-8)
- 3,4-Bis(bromomethyl)-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy Radical (CAS 229621-20-9)
- N-(6-(1H-Indol-6-yl)naphthalen-2-yl)thiophene-3-carboxamide (CAS 919362-71-3)
- Puwainaphycin F (CAS 1379577-47-5)
- 5-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-methyl-4H-1,2,4-triazole-3-thiol (CAS 897831-07-1)
- 5-Fluoro-2-methylpiperidine (CAS 1780453-16-8)
- cis-2-[2-(4-Methylphenyl)-2-oxoethyl]-cyclohexane-1-carboxylic acid (CAS 736136-31-5)
- Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate (CAS 78167-68-7)
- Insulin Degludec Impurity 1 (CAS 843666-26-2)
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