3-(5-Chloro-2-methoxyphenyl)propanoic acid CAS 5553-96-8
| CAS No. | 5553-96-8 |
| Molecular Formula | C10H11ClO3 |
| Molecular Weight | 214.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 3-(5-Chloro-2-methoxyphenyl)propanoic acid (C10H11ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
3-(5-Chloro-2-methoxyphenyl)propanoic acid (CAS 5553-96-8), molecular formula C10H11ClO3 and molecular weight 214.65 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11ClO3 |
| Molecular Weight | 214.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 4-Chloro-1-cyclopentyl-1H-pyrazole-3-carboxylic acid (CAS 1006451-33-7)
- 2-(4-Chloro-3-cyclopropyl-1h-pyrazol-1-yl)propanoic acid (CAS 1006490-23-8)
- 4-Chloro-1-cyclopentyl-1h-pyrazole-5-carboxylic acid (CAS 1006493-95-3)
- 6-Chloro-N-(2-methoxyethyl)pyridine-3-carboxamide (CAS 1016741-22-2)
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Recommended Standards
- 3-(4-Chlorophenyl)-2-methoxypropanoic acid (CAS 606493-11-2)
- 3,5-Dimethoxy-4-methylbenzoyl chloride (CAS 34523-76-7)
- 3-(4-Chloro-3-methylphenoxy)propanoic acid (CAS 91900-30-0)
- 3-Chloro-4-cyclohexyl-2,5-furandione (CAS 51487-40-2)
- 2-Bromopyridin-4-amine hydrochloride (CAS 1706431-09-5)
- 6-Chloro-4-fluoronicotinonitrile (CAS 1256820-16-2)
- 2-(4-Aminophenyl)-2-hydroxyacetic acid (CAS 13104-66-0)
- 1-Isobutyl-3-methyl-5-nitro-1h-pyrazole (CAS 1429418-84-7)
- 6-(2-Fluorophenyl)pyridazin-3-amine (CAS 1159818-36-6)
- 2-Chloro-6-fluoro-3-methylphenol (CAS 261762-90-7)
- 3-Phenylbutan-1-amine hydrochloride (CAS 1201907-52-9)
- Adipic Acid, Decyloctyl Ester (CAS 110-29-2)
- 4-Chloro-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline (CAS 264208-55-1)
- (Ser(PO?H?)2?2)-Tau Peptide (260-264) PAb Blocking trifluoroacetate salt (CAS 2022956-57-4)
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