5-Amino-6-chloroisoindoline-1,3-dione CAS 5566-48-3
| CAS No. | 5566-48-3 |
| Molecular Formula | C8H5ClN2O2 |
| Molecular Weight | 196.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 196.59 g/mol gives 5-Amino-6-chloroisoindoline-1,3-dione distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-Amino-6-chloroisoindoline-1,3-dione (CAS 5566-48-3), molecular formula C8H5ClN2O2 and molecular weight 196.59 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Amino-6-chloroisoindoline-1,3-dione (C8H5ClN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClN2O2 |
| Molecular Weight | 196.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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- 1-(4-Cyanobenzyl)-3-methyl-1H-pyrazole-4-carboxylic acid (CAS 1378626-99-3)
- 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1398923-95-9)
- [1-(3,4-Dichlorophenyl)-1H-1,2,3-triazol-4-yl]methyl N-phenylcarbamate (CAS 338419-30-0)
- 2,3-Dibromo-4,6-difluorothiophenol (CAS 1806351-24-5)
- Methyl 5-bromo-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzoate (CAS 1403257-49-7)
- Furagin (CAS 1672-88-4)
- Peptide Impurity 28 (CAS 1350456-64-2)
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