7-Chloro-6-(Trifluoromethyl)-1,2,4-Benzothiadiazine 1,1-Dioxide CAS 55933-18-1
| CAS No. | 55933-18-1 |
| Molecular Formula | C8H4ClF3N2O2S |
| Molecular Weight | 284.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 7-Chloro-6-(Trifluoromethyl)-1,2,4-Benzothiadiazine 1,1-Dioxide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 7-Chloro-6-(Trifluoromethyl)-1,2,4-Benzothiadiazine 1,1-Dioxide (CAS 55933-18-1), a certified reference material (molecular formula C8H4ClF3N2O2S, MW 284.64 g/mol) for analytical method development and quality control.
7-Chloro-6-(Trifluoromethyl)-1,2,4-Benzothiadiazine 1,1-Dioxide (C8H4ClF3N2O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF3N2O2S |
| Molecular Weight | 284.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)sulfonyl)acetonitrile (CAS 1823182-69-9)
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- 5-Chloro-6-[(3,4-difluorophenyl)amino]pyridine-3-carboxylic acid (CAS 1019466-14-8)
- 3-(3-Chloro-4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (CAS 1283108-59-7)
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Recommended Standards
- 6-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonyl chloride (CAS 2231234-38-9)
- 4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzene-1-sulfonyl chloride (CAS 2089731-83-7)
- Bortezomib Impurity N46 (CAS 85167-14-2)
- 2-(4-Chlorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile (CAS 142921-23-1)
- 2-(pyrrolidin-1-yl)-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 1042816-46-5)
- N-(4-bromophenyl)-2-cyano-3-(pyridin-4-yl)propanamide (CAS 483359-42-8)
- 4-Bromo-6-chloropicolinamide (CAS 1807072-80-5)
- 4-(Adamantan-1-ylmethoxy)-3-bromobenzonitrile (CAS 1494589-95-5)
- 4-(tert-Butoxycarbonyl)-1-(pyrazin-2-yl)piperazine-2-carboxylic acid (CAS 1261229-93-9)
- (2-Nitrophenyl)(3-nitrophenyl)methanone (CAS 60191-42-6)
- Amlodipine Impurity 156 (CAS CATO-C4X-1095156)
- Ethyl 2-(3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetate (CAS 1218789-53-7)
- 3-Chloropropyl-n-octylsulfoxide (CAS 3569-57-1)
- (Ser(PO?H?)3??·???)-Tau Peptide (379-408) trifluoroacetate salt (CAS 2022956-60-9)
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