Metoclopramide EP Impurity A CAS 5608-13-9
| CAS No. | 5608-13-9 |
| Molecular Formula | C16H24ClN3O3 |
| Molecular Weight | 341.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Metoclopramide EP Impurity A (CAS 5608-13-9) is a certified pharmaceutical impurity reference standard with the molecular formula C16H24ClN3O3 and a molecular weight of 341.83 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Metoclopramide EP Impurity A is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 341.83 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Metoclopramide EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H24ClN3O3 |
| Molecular Weight | 341.83 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Metoclopramide Standards
- Metoclopramide Impurity 101 (CAS CATO-C4X-1415101)
- Metoclopramide Impurity 113 (CAS CATO-C4X-1415113)
- Metoclopramide Impurity 21 (CAS 25195-05-5)
- Metoclopramide Impurity 111 (CAS CATO-C4X-1415111)
- Metoclopramide Impurity 100 (CAS CATO-C4X-1415100)
- Metoclopramide impurity 47 (CAS CATO-C4X-141547)
- Metoclopramide Impurity 106 (CAS CATO-C4X-1415106)
- Metoclopramide impurity 63 (CAS CATO-C4X-141563)
Recommended Standards
- tert-Butyl (2R,5S)-5-(4-chlorobenzyl)-2-(hydroxymethyl)morpholine-4-carboxylate (CAS 2088454-25-3)
- Zolpidem Impurity 19 (CAS CATO-C4X-148619)
- N-(1-(1H-benzo[d]imidazol-2-yl)-3-methylbutyl)-2-chlorobenzamide (CAS 338410-72-3)
- Tepraloxydim (CAS 149979-41-9)
- Parecoxib Impurity 71 (CAS 2304623-38-7)
- Ilaprazole Impurity 223 (CAS CATO-C4X-1130223)
- Nicotinic Acid EP Impurity E (CAS 55-22-1)
- (S)-3-Pyrrolidinemethanol (CAS 110013-19-9)
- tert-Butyl 3-(4-chlorophenyl)-3-hydroxypiperidine-1-carboxylate (CAS 951624-09-2)
- tert-Butyl (6-chloro-4-formylpyridin-2-yl)carbamate (CAS 1060801-14-0)
- PEG2-bis(phosphonic acid) (CAS 116604-42-3)
- (1R,2S,4S)-7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid (CAS 1034079-37-2)
- tert-Butyl N-[(5-fluoro-2-hydroxyphenyl)methyl]carbamate (CAS 1881329-09-4)
- ([13C6]Leu14)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802078-39-2)
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