N-(2-chloroacetyl)-2-(2-oxopyrrolidin-1-yl)acetamide CAS 561002-06-0
| CAS No. | 561002-06-0 |
| Molecular Formula | C8H11ClN2O3 |
| Molecular Weight | 218.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(2-chloroacetyl)-2-(2-oxopyrrolidin-1-yl)acetamide.
CATO supplies N-(2-chloroacetyl)-2-(2-oxopyrrolidin-1-yl)acetamide (CAS 561002-06-0), a certified reference material (molecular formula C8H11ClN2O3, MW 218.64 g/mol) for analytical method development and quality control.
Structurally, N-(2-chloroacetyl)-2-(2-oxopyrrolidin-1-yl)acetamide (C8H11ClN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 218.64 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(2-chloroacetyl)-2-(2-oxopyrrolidin-1-yl)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H11ClN2O3 |
| Molecular Weight | 218.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- 2-(5-(2-Chloroacetyl)thiophen-2-yl)acetic acid (CAS 175203-15-3)
- 2-[(2-Chloroacetyl)amino]-3-thiophenecarboxamide (CAS 610274-69-6)
- 1-(2-Chloroacetyl)-n-methylpiperidine-4-carboxamide (CAS 1153301-68-8)
- n-[1-(2-chloroacetyl)piperidin-3-yl]acetamide (CAS 1182969-06-7)
- N-(1-(2-Chloroacetyl)pyrrolidin-3-yl)-N-methylacetamide (CAS 1353946-89-0)
- N-((1-(2-Chloroacetyl)pyrrolidin-2-yl)methyl)acetamide (CAS 1353978-34-3)
- N-((1-(2-Chloroacetyl)pyrrolidin-3-yl)methyl)acetamide (CAS 1353988-65-4)
- 1-(2-Chloroacetyl)-2,2,5,5-tetramethylimidazolidin-4-one (CAS 209336-83-4)
Recommended Standards
- 7-Chlorodibenzo[b,d]furan-1-ol (CAS 2226916-90-9)
- 928713-84-2 2-(4-Chlorophenyl)pyrimidine-5-carbaldehyde DTXSID10589775 (CAS 928713-84-2)
- 7-Chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carbonitrile (CAS 89479-59-4)
- Letrozole Impurity 14 (CAS 2451658-74-3)
- 2-Chloro-N-cyclopropyl-N-(pyridin-4-ylmethyl)acetamide (CAS 1183789-52-7)
- (4S,5S)-4,5-bis(fluoromethyl)-2,2-dimethyl-1,3-dioxolane (CAS 84409-70-1)
- 1-Methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid (CAS 32286-99-0)
- [(2-amino-4-methyl-1,3-thiazol-5-yl)thio]acetonitrile (CAS 1000933-55-0)
- (1,5-Diphenyl-1H-pyrazol-3-yl)methanol (CAS 945984-78-1)
- (1R)-1-[(1S)-1-[Bis(3,5-bis(trifluoromethyl)phenyl)phosphino]ethyl]-2-[2-(diphenylphosphino)phenyl]ferrocene (acc to CAS) (S)-1-{(SP)-2-[2-(Diphenylphosphino)phenyl]ferrocenyl}ethylbis[3,5-bis-(trifluoromethyl)phenyl]phosphine 849925-17-3 Walphos SL-W001-2 (CAS 849925-17-3)
- 7-(Allyloxy)-4,8-dimethyl-2H-chromen-2-one (CAS 3993-43-9)
- 2-(Diethylamino)-2-(p-tolyl)acetonitrile (CAS 943611-24-3)
- (5S)-5-(hydroxymethyl)-1-methylpyrrolidin-2-one (CAS 122663-19-8)
- KALA Amphipathic Peptide (CAS 187987-64-0)
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