4-(Chloromethyl)quinoline CAS 5632-17-7
| CAS No. | 5632-17-7 |
| Molecular Formula | C10H8ClN |
| Molecular Weight | 177.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(Chloromethyl)quinoline is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(Chloromethyl)quinoline (CAS 5632-17-7), molecular formula C10H8ClN and molecular weight 177.63 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Chloromethyl)quinoline (C10H8ClN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(Chloromethyl)quinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H8ClN |
| Molecular Weight | 177.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- 3-(Chloromethyl)quinoline, 97% (CAS 104325-51-1)
- 5-(Chloromethyl)quinoline (CAS 110333-07-8)
- 4-(Chloromethyl)isoquinoline (CAS 120277-71-6)
- 1-[2-(Chloromethyl)morpholin-4-yl]ethan-1-one (CAS 1245938-95-7)
- 2-(2-(Chloromethyl)pyrrolidin-1-yl)acetic acid (CAS 1353947-13-3)
- 2-(3-(Chloromethyl)pyrrolidin-1-yl)acetic acid (CAS 1353978-25-2)
- 4-(chloromethyl)-[1,3]dioxolo[4,5-c]pyridine (CAS 139645-24-2)
- 3-(Chloromethyl)isoquinoline (CAS 147937-36-8)
Recommended Standards
- 4-(2-Chloroallyl)benzonitrile (CAS 731772-74-0)
- 4-amino-6-chloro-2-methyl-pyrimidine-5-carbaldehyde (CAS 51290-87-0)
- 3-Chloronaphthalen-2-amine (CAS 38410-42-3)
- 4-Chloro-3-methylquinoline (CAS 63136-60-7)
- 7-(2-Hydroxy-3-phenoxypropyl)-3-methyl-8-(piperidin-1-yl)-1H-purine-2,6(3H,7H)-dione (CAS 102838-04-0)
- 1-(3-methyloxetan-3-yl)ethanamine;hemi(oxalic acid) (CAS 2102409-45-8)
- 2-Mesityl-2-phenylacetonitrile (CAS 32189-29-0)
- ((R)-4-Hydroxy-4-methyl-Orn(CPM-β-Mpa)7)-Phalloidin (CAS 1926163-49-6)
- 3-(Furan-2-yl)-1,4-dioxane-2-carboxylic acid (CAS 1706444-75-8)
- 2-(Morpholine-4-carbonyl)-3-(5-(3-nitrophenyl)furan-2-yl)acrylonitrile (CAS 300700-39-4)
- 4-Hydroxy-2-oxo-N,1-diphenyl-2,5-dihydro-1H-pyrrole-3-carboxamide (CAS 1221504-61-5)
- 8-Amino-N-(4-(dimethylamino)phenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide (CAS 889955-92-4)
- (4-Cyclopropoxy-2-ethylpyridin-3-yl)methanamine (CAS 1243310-63-5)
- A-18-F-NH2; Morphine Modulating Neuropeptide (CAS 99588-52-0)
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