3-Amino-N-(5-chloropyrimidin-2-yl)benzenesulfonamide CAS 565-36-6
| CAS No. | 565-36-6 |
| Molecular Formula | C10H9ClN4O2S |
| Molecular Weight | 284.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Amino-N-(5-chloropyrimidin-2-yl)benzenesulfonamide.
CATO supplies 3-Amino-N-(5-chloropyrimidin-2-yl)benzenesulfonamide (CAS 565-36-6), a certified reference material (molecular formula C10H9ClN4O2S, MW 284.72 g/mol) for analytical method development and quality control.
3-Amino-N-(5-chloropyrimidin-2-yl)benzenesulfonamide (C10H9ClN4O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9ClN4O2S |
| Molecular Weight | 284.72 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Amino Standards
- 4-Amino-N-(5-chloropyrimidin-2-yl)benzenesulfonamide (CAS 4482-46-6)
- 5-((3-Amino-6-methoxypyridin-2-yl)thio)-4-chloropyridazin-3(2H)-one (CAS 86109-81-1)
- N-(3-amino-4-chloro-2-fluorophenyl)-3-fluoro-1-Propanesulfonamide (CAS 1269421-25-1)
- 2-[(3-amino-4-chlorophenyl)methyl]-1,2-dihydroisoquinolin-1-one (CAS 1557753-78-2)
- 4-((6-Amino-2-chloro-9h-purin-9-yl)methyl)benzonitrile (CAS 927822-40-0)
- Ethyl 1-amino-7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 88569-30-6)
- 3-(Boc-amino)-3-(4-chlorophenyl)-1-propylamine (CAS 885595-59-5)
- (S)-2-Amino-N-((6-chloropyridazin-3-yl)methyl)-N-isopropyl-3-methylbutanamide (CAS 1354010-54-0)
Recommended Standards
- 3-(7-Chloro-4-oxo-2-sulfanyl-3,4-dihydroquinazolin-3-yl)propanoic acid (CAS 852940-56-8)
- 4-((6-Chlorobenzo[d]thiazol-2-yl)amino)-4-oxobutanoic acid (CAS 352699-95-7)
- 3-((6-Methylpyrazin-2-yl)oxy)benzene-1-sulfonyl chloride (CAS 926921-65-5)
- 4-((6-Methylpyrazin-2-yl)oxy)benzenesulfonyl chloride (CAS 926921-66-6)
- (3α,5β,12α)-3,12-Dihydroxy-7-oxocholan-24-oic acid methyl ester (CAS 10538-65-5)
- 2-(4,7-Dichloro-2-(4-fluorophenyl)-1H-indol-3-yl)ethanamine (CAS 881040-37-5)
- 3-Hydroxy-2-(2-hydroxyphenyl)-4H-1-benzopyran-4-one (CAS 6068-76-4)
- (3,5-Dimorpholinophenyl)boronic acid (CAS 2225181-09-7)
- 3,5-Difluoro-4-((tetrahydro-2h-pyran-4-yl)oxy)aniline (CAS 1248914-51-3)
- N-(3-Aminophenyl)-2-phenoxybutanamide (CAS 1020722-36-4)
- Carbol fuchsin (CAS 4197-24-4)
- 2-Methyl-6-nitrobenzene-1,4-diamine (CAS 155379-82-1)
- Ethyl 2-(1,8-naphthyridin-2-yl)acetate (CAS 339536-82-2)
- D-Gln19-Tirzepatide (CAS CATO-CPTD788915)
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