(Z)-3-(4-chlorophenyl)acrylic acid CAS 5676-62-0
| CAS No. | 5676-62-0 |
| Molecular Formula | C9H7ClO2 |
| Molecular Weight | 182.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(Z)-3-(4-chlorophenyl)acrylic acid (CAS 5676-62-0), molecular formula C9H7ClO2 and molecular weight 182.60 g/mol, is a CATO reference standard with documented purity and traceability.
(Z)-3-(4-chlorophenyl)acrylic acid (C9H7ClO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7ClO2 |
| Molecular Weight | 182.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Z Standards
- 1-(4-Chlorophenyl)propane-1,2-dione (CAS 10557-21-8)
- (Z)-3-(3-Chlorophenyl)acrylic acid (CAS 14290-89-2)
- (E)-3-(2-Chlorophenyl)acrylic acid (CAS 939-58-2)
- (Z)-3-(2-Chlorophenyl)acrylic acid (CAS 704-96-1)
- 1-(2-Chlorophenyl)propane-1,2-dione (CAS 64497-33-2)
- 2-(3-Chlorophenyl)propanedial (CAS 74963-16-9)
- 2-(4-Chlorophenyl)malondialdehyde (CAS 205676-17-1)
- 2-(4-Chlorophenyl)prop-2-enoic acid (CAS 51747-43-4)
Recommended Standards
- (E)-3-(5-Chloro-2-hydroxyphenyl)acrylaldehyde (CAS 33538-98-6)
- 2-(2-Methoxyethoxy)ethyl carbonochloridate (CAS 50689-80-0)
- (5-Chlorobenzofuran-3-yl)methanol (CAS 650616-58-3)
- 2-(4-Chloro-3-methylphenyl)-2-oxoacetaldehyde (CAS 93290-96-1)
- 2-Methyl-6-(phenylamino)nicotinonitrile (CAS 1355237-82-9)
- 2-Benzoyl-4-chlorobenzaldehyde (CAS 23864-89-3)
- 2-Bromophenyl 2,2,2-trifluoroacetate (CAS 36613-46-4)
- 5-Hydrazinyl-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (CAS 112734-99-3)
- 5-(Bromomethyl)-1-methyl-1h-imidazole (CAS 499770-71-7)
- Imidazo[1,5-a]pyrido[3,2-e]pyrazin-6(5H)-one (CAS 240815-49-0)
- 3-(Aminomethyl)-N-isopropylpyridin-2-amine hydrochloride (CAS 1353945-31-9)
- rel-(1R,2S)-3,3-Difluoro-[1,1'-bi(cyclopropane)]-2-carboxylic acid (CAS 2744526-57-4)
- 2-Imino-6-methoxy-2H-chromene-3-carboxamide (CAS 71586-41-9)
- Tirzepatide (CAS 2023788-19-2)
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