2-chloro-6-(pyrrolidin-1-yl)pyridine-4-carboxylic acid CAS 56930-72-4
| CAS No. | 56930-72-4 |
| Molecular Formula | C10H11ClN2O2 |
| Molecular Weight | 226.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-chloro-6-(pyrrolidin-1-yl)pyridine-4-carboxylic acid (C10H11ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-chloro-6-(pyrrolidin-1-yl)pyridine-4-carboxylic acid (CAS 56930-72-4) is a high-purity analytical reference standard with the molecular formula C10H11ClN2O2 and a molecular weight of 226.66 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-chloro-6-(pyrrolidin-1-yl)pyridine-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H11ClN2O2 |
| Molecular Weight | 226.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
- 5-Chloro-6-(pyrrolidin-1-yl)nicotinic acid (CAS 1019127-02-6)
- 2-chloro-6-(cyclopropylmethoxy)benzoic acid (CAS 1020934-87-5)
- (3-Chloro-5-methoxy-4-(prop-2-yn-1-yloxy)phenyl)methanol (CAS 1030765-35-5)
- 1-(5-Chloro-2-methoxyphenyl)cyclopropane-1-carboxylic acid (CAS 1039952-36-7)
- Ethyl 4-chloro-2-cyclopropylpyrimidine-5-carboxylate (CAS 1044770-40-2)
- Benzyl 2-chloro-3-oxobutanoate (CAS 104517-65-9)
- 2-(4-Chloro-2-nitrophenyl)pyrrolidine (CAS 1092291-34-3)
- 1-(2-Chloro-phenyl)-2-(1,3-dioxolan-2-yl)-ethanone (CAS 110251-20-2)
Recommended Standards
- 2-Chloro-1-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-ethanone (CAS 887694-24-8)
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- 2-Chloro-1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-propan-1-one (CAS 879045-01-9)
- 2-Chlorobenzyl 3-oxobutanoate (CAS 61312-26-3)
- 5-Benzyl-1,2,3-thiadiazole-4-carboxylic acid (CAS 1707378-49-1)
- Tert-butyl cyclopropyl(piperidin-2-ylmethyl)carbamate (CAS 1353957-18-2)
- 4-((Azetidin-3-yloxy)methyl)pyridine (CAS 1309315-36-3)
- (5-Fluoroindol-1-yl)acetic acid (CAS 796071-90-4)
- 4-(4-Chlorophenyl)-2-(4-fluorophenyl)phthalazin-1(2H)-one (CAS 338756-80-2)
- 4-(chloromethyl)-2-(2-fluorophenyl)-1,3-thiazole (CAS 138128-84-4)
- (11aS)-3,7-Bis(4-chlorophenyl)-10,11,12,13-tetrahydro-5-hydroxy-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin (CAS 1258327-05-7)
- 2-Amino-6-methyl-N-(o-tolyl)benzamide (CAS 371244-06-3)
- 1-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-fluoroethanone (CAS 38941-41-2)
- Peptide Impurity 82 (CAS 10491-78-8)
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