Ethinylestradiol EP Impurity L CAS 57-91-0
| CAS No. | 57-91-0 |
| Molecular Formula | C18H24O2 |
| Molecular Weight | 272.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ethinylestradiol EP Impurity L is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ethinylestradiol EP Impurity L (CAS 57-91-0, C18H24O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, Ethinylestradiol EP Impurity L is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 272.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ethinylestradiol EP Impurity L meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H24O2 |
| Molecular Weight | 272.38 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Ethinylestradiol Standards
- Ethinylestradiol EP Impurity B (CAS 1231-96-5)
- Ethinylestradiol EP Impurity I (CAS 67703-68-8)
- 17alpha-Ethinylestradiol (CAS 57-63-6)
- Ethinylestradiol EP Impurity A (CAS 4717-38-8)
- Ethinylestradiol-13C2 (CAS 2483735-63-1)
- Ethinylestradiol-d7 (CAS 2714413-57-5)
- Ethinylestradiol-d9 (CAS CATO-C4X-21909)
- Ethinylestradiol EP Impurity G (CAS 38002-18-5)
Recommended Standards
- Estradiol Impurity 23 (CAS 1093411-48-3)
- Estradiol Impurity 55 (CAS CATO-C4X-163655)
- Estradiol Impurity 22 (CAS CATO-C4X-163622)
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