Celiprolol impurity 8 CAS 57471-32-6
| CAS No. | 57471-32-6 |
| Molecular Formula | C8H9NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 187.62 g/mol gives Celiprolol impurity 8 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Celiprolol impurity 8 (CAS 57471-32-6, C8H9NO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H9NO2HCl, Celiprolol impurity 8 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 187.62 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Celiprolol impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H9NO2 HCl |
| Molecular Weight | 187.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Celiprolol Standards
- (S)-(-)-Celiprolol Hydrochloride (CAS 102293-39-0)
- Celiprolol-d9 Hydrochloride (CAS 1215535-20-8)
- Celiprolol Hydrochloride EP Impurity B (CAS 125579-40-0)
- (R)-(+)-Celiprolol Hydrochloride (CAS 125638-91-7)
- (R)-(+)-Celiprolol-d9 Hydrochloride (CAS 1330045-90-3)
- (S)-(-)-Celiprolol-d9 Hydrochloride (CAS 1330266-42-6)
- Celiprolol (CAS 56980-93-9)
- Celiprolol Hydrochloride EP Impurity A (CAS 56980-94-0)
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- Apalutamide Impurity 49 (CAS CATO-C4X-274949)
- Tetrabenazine Impurity 4 (CAS 63708-05-4)
- Peptide Impurity 24 (CAS CATO-CPTD788824)
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