2-(4-Methoxyphenyl)thiazole-4-carboxylic acid CAS 57677-80-2

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(4-Methoxyphenyl)thiazole-4-carboxylic acid.

2-(4-Methoxyphenyl)thiazole-4-carboxylic acid (CAS 57677-80-2), molecular formula C11H9NO3S and molecular weight 235.26 g/mol, is a CATO reference standard with documented purity and traceability.

Structurally, 2-(4-Methoxyphenyl)thiazole-4-carboxylic acid (C11H9NO3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 235.26 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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