Argatroban Impurity 46 CAS 57876-69-4
| CAS No. | 57876-69-4 |
| Molecular Formula | C10H8ClN |
| Molecular Weight | 177.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Argatroban Impurity 46 (CAS 57876-69-4), a pharmacopoeial impurity reference standard (molecular formula C10H8ClN, MW 177.63 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Argatroban Impurity 46 (C10H8ClN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H8ClN |
| Molecular Weight | 177.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Argatroban Standards
- Argatroban Impurity 72 (CAS 66937-93-7)
- Argatroban Impurity 20 (CAS 78306-52-2)
- Argatroban Impurity 27 (CAS 74892-82-3)
- Argatroban Impurity 8 (CAS 79199-61-4)
- Argatroban Impurity 9 (CAS 79199-62-5)
- Argatroban Impurity 85 (CAS CATO-C4X-100785)
- Argatroban Impurity 109 (CAS 1515961-07-5)
- Argatroban Impurity 3 (CAS 20668-20-6)
Recommended Standards
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