Hydrochlorothiazide EP Impurity A CAS 58-94-6
| CAS No. | 58-94-6 |
| Molecular Formula | C7H6ClN3O4S2 |
| Molecular Weight | 295.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Hydrochlorothiazide EP Impurity A (C7H6ClN3O4S2) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Hydrochlorothiazide EP Impurity A (CAS 58-94-6, C7H6ClN3O4S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Hydrochlorothiazide EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6ClN3O4S2 |
| Molecular Weight | 295.72 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide (CAS 58-93-5)
- Hydrochlorothiazide impurity 48 (CAS CATO-C4X-117748)
- Hydrochlorothiazide Impurity 56 (CAS CATO-C4X-117756)
- Hydrochlorothiazide-d2 (CAS 1219798-89-6)
- Hydrochlorothiazide Impurity 22 (CAS 90794-87-9)
- Hydrochlorothiazide-13C,d2 (CAS 1190006-03-1)
- Hydrochlorothiazide Impurity 32 (CAS CATO-C4X-117732)
- Hydrochlorothiazide Impurity 33 (CAS CATO-C4X-117733)
Recommended Standards
- 70374-51-5 Methyl 6-chloro-4-hydroxy-1,1-dioxo-1,2-dihydro-1lambda~6~-thieno[2,3-e][1,2]thiazine-3-carboxylate DTXSID50716407 (CAS 70374-51-5)
- Norfloxacin Impurity 61 (CAS CATO-C4X-146861)
- Methyl N-(3-chloro-4-fluorophenyl)-N-(methylsulfonyl)glycinate (CAS 831184-33-9)
- Lornoxicam Impurity 13 (CAS 2322849-92-1)
- Nicotinamide Impurity 3 (CAS 24292-60-2)
- Trospium Impurity 5 (CAS CATO-C4X-20385)
- Tirzepatide Impurity 35 (CAS CATO-C4X-324035)
- Methyl 2-methyl-5-(sulfamoylmethyl)furan-3-carboxylate (CAS 1248172-71-5)
- 6-Iodo-9H-purin-2-amine (CAS 19690-23-4)
- 4-(Chloromethyl)-N-(4-fluorophenyl)benzamide (CAS 500568-39-8)
- 2-[(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)formamido]acetic acid (CAS 89937-94-0)
- 3-Isopropylpyridin-4-ol (CAS 1243373-60-5)
- 6-(4-Chlorophenyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diamine (CAS 23935-90-2)
- Semaglutide impurity 29 (CAS 110990-08-4)
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