Estriol Impurity N1 CAS 58001-91-5
| CAS No. | 58001-91-5 |
| Molecular Formula | C18H24O4 |
| Molecular Weight | 304.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Estriol Impurity N1 is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Estriol Impurity N1 (CAS 58001-91-5) is a certified pharmaceutical impurity reference standard with the molecular formula C18H24O4 and a molecular weight of 304.38 g/mol.
Estriol Impurity N1 (C18H24O4) contains a flavonoid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Estriol Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H24O4 |
| Molecular Weight | 304.38 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
Related Estriol Standards
Recommended Standards
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- Ethyl 2-(6-methoxy-1-oxo-2-propyl-1,2,3,4-tetrahydronaphthalen-2-yl)acetate (CAS 2219321-11-4)
- dibutyl 2-benzylidenemalonate (CAS 59832-50-7)
- Ethyl 3-(4-(4-ethylpiperazin-1-yl)phenyl)-3-oxopropanoate (CAS 940284-82-2)
- Tenofovir disoproxil Impurity 39 (CAS 87-42-3)
- Clindamycin Impurity 86 (CAS CATO-C4X-134186)
- Dapagliflozin Impurity 8 (CAS 1662702-90-0)
- 2-(4-Propionylphenoxy)acetamide (CAS 445232-54-2)
- Methyl 2-Fluoro-4-methoxybenzoate (CAS 128272-26-4)
- 4-(Difluoromethyl)-3-iodo-6-methoxypicolinaldehyde (CAS 1805095-13-9)
- Lercanidipine Related Compound 2 (CAS 67622-86-0)
- (3R,5R)-3-amino-5-methylpyrrolidin-2-one hydrochloride (CAS 2417778-21-1)
- Benzoic acid, 4-(acetylamino)-3-nitro-, phenyl ester (CAS 193888-74-3)
- 59880-97-6 Chemotactic peptide F-Met-Leu-Phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-L-methionyl-L-leucyl-L-phenylalanine N-Formyl-Met-Leu-Phe N-Formylmethionine leucyl-phenylalanine fMLF fMLP (misnomer but widely used) (CAS 59880-97-6)
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