3-Hydroxy-2-naphthaldehyde CAS 581-71-5
| CAS No. | 581-71-5 |
| Molecular Formula | C11H8O2 |
| Molecular Weight | 172.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Hydroxy-2-naphthaldehyde.
3-Hydroxy-2-naphthaldehyde (CAS 581-71-5) is a high-purity analytical reference standard with the molecular formula C11H8O2 and a molecular weight of 172.18 g/mol.
The molecular framework of 3-Hydroxy-2-naphthaldehyde (C11H8O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Hydroxy-2-naphthaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8O2 |
| Molecular Weight | 172.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
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- 2-((3,6-Dichloropyridazin-4-yl)amino)-3-methylpentan-1-ol (CAS 2060032-30-4)
- 5-Fluoro-1H-indazole-3-carbonitrile (CAS 1360953-63-4)
- Cyclopropyl(2-hydroxy-3,5-dimethylphenyl)methanone (CAS 1249097-38-8)
- N-ethyl-2-(methylamino)acetamide (CAS 225229-02-7)
- 2-((5-Acetamido-1,3,4-thiadiazol-2-yl)thio)acetic acid (CAS 328288-81-9)
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