(E)-3-(3-Chloro-4-methoxyphenyl)acrylic acid CAS 58236-76-3
| CAS No. | 58236-76-3 |
| Molecular Formula | C10H9ClO3 |
| Molecular Weight | 212.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
(E)-3-(3-Chloro-4-methoxyphenyl)acrylic acid (CAS 58236-76-3), molecular formula C10H9ClO3 and molecular weight 212.63 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (E)-3-(3-Chloro-4-methoxyphenyl)acrylic acid (C10H9ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H9ClO3 |
| Molecular Weight | 212.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
Related E Standards
- 4-Chloro-2-cyano-3-fluorophenylisothiocyanate (CAS 1000577-97-8)
- 2-(5-chloro-2,3-dihydro-1-benzofuran-2-yl)acetic acid (CAS 1018251-39-2)
- 2-Chloro-3-cyclopropoxybenzoic acid (CAS 1036204-45-1)
- Ethyl 2-chloro-6-formylbenzoate (CAS 1049677-64-6)
- 7-Chloro-3-ethyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (CAS 105544-35-2)
- 8-Chloro-7-methoxychroman-4-one (CAS 1155264-20-2)
- Methyl 2-chloro-6-cyclopropylpyrimidine-4-carboxylate (CAS 1175925-40-2)
- 3-Chloro-2-cyclopropoxybenzoic acid (CAS 1243318-45-7)
Recommended Standards
- (2S,3S,4S,5R,6R)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol (CAS 4990-84-5)
- (e)-3-(5-Chloro-2-methoxyphenyl)acrylic acid (CAS 90798-07-5)
- (2S,3R,4S,5R,6S)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol (CAS 21307-62-0)
- (R)-2-(6-Chloro-2,3-dihydrobenzofuran-3-yl)acetic acid (CAS 2841541-44-2)
- N-(4-chlorophenyl)-1-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)-N-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 400083-08-1)
- N-((1-methylpyrrolidin-2-yl)methyl)ethanamine (CAS 68339-47-9)
- 3-Chloropyridine-2-sulfonamide (CAS 96009-29-9)
- N-Acetyl-S-(1,1,2,2-Tetrafluoroethyl)-1-Cysteine (CAS 119018-04-1)
- Amisulpride Impurity 19 (CAS 483304-03-6)
- tert-butyl allyl(3,5-dinitrobenzyl)carbamate (CAS 2009210-29-9)
- Ethyl 2-methyl-2H-indazole-4-carboxylate (CAS 1353497-21-8)
- Zolmitriptan Impurity 29 (CAS CATO-C4X-135129)
- Bis(4-((4-(tetradecyloxy)benzoyl)oxy)phenyl) adipate (CAS 848139-54-8)
- Autocamtide-2-Related Inhibitory Peptide TFA (CAS 167114-91-2（free base）)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com