Ethyl 7-chloro-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate CAS 58347-48-1
| CAS No. | 58347-48-1 |
| Molecular Formula | C10H10ClN3O2 |
| Molecular Weight | 239.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 7-chloro-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 58347-48-1), molecular formula C10H10ClN3O2 and molecular weight 239.66 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 7-chloro-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate (C10H10ClN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10ClN3O2 |
| Molecular Weight | 239.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Ethyl Standards
- Ethyl 7-chloro-2-methyl-2H-pyrazolo[4,3-b]pyridine-6-carboxylate (CAS 100478-09-9)
- 2-Chloro-N-((2-hydroxy-1H-benzo[d]imidazol-6-yl)methyl)acetamide (CAS 100698-50-8)
- 4-[(2-Chloro-3-pyridinyl)carbonyl]-2-piperazinone (CAS 1016743-92-2)
- 4-((3-Chloro-4-methylphenyl)amino)-4-oxobut-2-enoic acid (CAS 116081-44-8)
- 2-Chloro-N-(4,6-dimethyl-isoxazolo[5,4-b]pyridin-3-yl)-acetamide (CAS 1171935-26-4)
- 4-Chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid (CAS 1184918-12-4)
- 4-Chloro-5-methoxyindole-3-acetic acid (CAS 1227578-32-6)
- 2-(4-Chloro-7-methoxy-1H-indol-3-yl)acetic acid (CAS 1227593-53-4)
Recommended Standards
- Ethyl 7-chloro-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate (CAS 223141-46-6)
- Ethyl 8-chloro-2-methylimidazo[1,2-b]pyridazine-7-carboxylate (CAS 2748770-28-5)
- Ethyl 6-chloro-3-methylimidazo[1,2-b]pyridazine-2-carboxylate (CAS 215530-92-0)
- Meseclazone (CAS 29053-27-8)
- ((3-Bromothiophen-2-yl)methyl)hydrazine (CAS 1248380-85-9)
- 1-[2-hydroxy-3-(methylamino)propyl]pyrrolidin-2-one (CAS 1019476-49-3)
- 1-Thia-4-azaspiro[5.5]Undecane 1,1-dioxide (CAS 1384431-33-7)
- Ethyl 3-Pyridylacetate (CAS 39931-77-6)
- N-Methyl-2-oxopyrrolidine-1-carboxamide (CAS 63987-03-1)
- 3-(Dimethylamino)butanoic acid (CAS 758665-04-2)
- (R)-3-(2-Methylbenzyl)piperazin-2-one (CAS 1240588-61-7)
- 1-Ethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 404586-53-4)
- 5-(Methoxymethyl)-1,2-oxazole-3-carbonitrile (CAS 1463940-00-2)
- Tirzepatide Impurity 15 (CAS CATO-C4X-324015)
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