4-(4-Fluorophenyl)-1H-pyrazol-5-amine CAS 5848-04-4
| CAS No. | 5848-04-4 |
| Molecular Formula | C9H8FN3 |
| Molecular Weight | 177.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(4-Fluorophenyl)-1H-pyrazol-5-amine.
4-(4-Fluorophenyl)-1H-pyrazol-5-amine (CAS 5848-04-4) is a high-purity analytical reference standard with the molecular formula C9H8FN3 and a molecular weight of 177.18 g/mol.
The molecular framework of 4-(4-Fluorophenyl)-1H-pyrazol-5-amine (C9H8FN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(4-Fluorophenyl)-1H-pyrazol-5-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8FN3 |
| Molecular Weight | 177.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Fluorophenyl Standards
- 3-(3-Fluorophenyl)-1H-pyrazol-5-amine (CAS 1028842-99-0)
- 1-(2-Fluorophenyl)-1H-pyrazol-5-amine (CAS 1056999-19-9)
- 1-(3-Fluorophenyl)-1h-pyrazol-5-amine (CAS 1056999-20-2)
- 3-(4-Fluorophenyl)-2-methyl-3-oxopropanenitrile (CAS 1094267-29-4)
- 5-(2-Fluorophenyl)-3-methyl-1h-1,2,4-triazole (CAS 1094563-94-6)
- 5-(3-Fluorophenyl)-3-methyl-1H-1,2,4-triazole (CAS 1094688-07-9)
- 1-(2-Fluorophenyl)-1H-pyrazol-4-amine (CAS 1153040-48-2)
- 1-(4-Fluorophenyl)-1h-pyrazol-4-amine (CAS 1156602-69-5)
Recommended Standards
- 4-(3-Fluorophenyl)-1,2-dihydro-3h-pyrazol-3-imine (CAS 301373-68-2)
- 4-(4-Fluorophenyl)-1H-pyrazol-5-amine (CAS 5848-05-5)
- 3-fluoro-6-methoxyquinoline (CAS 426842-85-5)
- 4-(4-Fluorophenyl)-4-oxobutanenitrile (CAS 756489-25-5)
- 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzaldehyde (CAS 76620-02-5)
- Ethyl 4-cyanobutanoate (CAS 10444-38-9)
- 2-(2-(2-Fluoro-5-methylphenoxy)ethyl)-1,3-dioxolane (CAS 1443342-85-5)
- 1-(2-Methoxypyridin-4-yl)propan-1-one (CAS 880767-50-0)
- 7-(Piperidin-1-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one (CAS 1707378-86-6)
- 4,4'-Azanediyldibenzoic acid (CAS 20800-00-4)
- 3-Amino-5,5-dimethylpyrrolidin-2-one hydrochloride (CAS 1445600-59-8)
- 2-Methylbenzene-1,4-diamine dihydrochloride (CAS 615-45-2)
- 4-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2-{[3-(trifluoromethyl)phenyl]methyl}-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidine-1,3-dione (CAS 1775402-65-7)
- Cycloaspeptide D (CAS 691363-62-9)
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