Polaprezinc Impurity 4 CAS 5853-00-9
| CAS No. | 5853-00-9 |
| Molecular Formula | C9H14N4O3 |
| Molecular Weight | 226.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Polaprezinc Impurity 4.
As a process- or degradation-related impurity, Polaprezinc Impurity 4 (CAS 5853-00-9, C9H14N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Polaprezinc Impurity 4 (C9H14N4O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 226.23 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H14N4O3 |
| Molecular Weight | 226.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 4 |
Related Polaprezinc Standards
- Polaprezinc impurity 26 (CAS CATO-C4X-182126)
- Polaprezinc Impurity 12 (CAS 19357-01-8)
- Polaprezinc Impurity 10 (CAS 3339-73-9)
- Polaprezinc Impurity 3 (CAS 103646-38-4)
- Polaprezinc impurity 28 (CAS CATO-C4X-182128)
- Polaprezinc Impurity 2 (CAS 17332-34-2)
- Polaprezinc Impurity 23 (CAS 19532-95-7)
- Polaprezinc Impurity 1 (CAS 5323-50-2)
Recommended Standards
- Epinephrine /Adrenaline Impurity 118 (CAS CATO-C4X-1849118)
- Atropine Impurity 11 (CAS 13025-99-5)
- Sodium Cromoglicate Impurity 9 (CAS 3361-18-0)
- N-Nitroso Ondansetron impurity 29 (CAS CATO-C4X-139429)
- Rosuvastatin Impurity 124 (CAS 615263-60-0)
- Ibandronic Impurity 5 Sodium salt (CAS 128202-57-3（free base）)
- N-Nitroso Nafamostat impurity 118 (CAS CATO-C4X-1332118)
- Acetohexamide (CAS 968-81-0)
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- (Sar1)-Angiotensin II (CAS 51833-69-3)
- n,n-Bis(butan-2-yl)-2-chloroacetamide (CAS 32322-33-1)
- 3-(Difluoromethyl)-5-(hydroxymethyl)-4-(trifluoromethyl)picolinonitrile (CAS 1805503-72-3)
- 2-Bromo-4-chloro-6-fluoro-1H-benzo[d]imidazole (CAS 1388070-38-9)
- Delicious Peptide (bovine) (CAS 73984-05-1)
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