Piperazine Impurity 64 CAS 5854-18-2
| CAS No. | 5854-18-2 |
| Molecular Formula | C13H14O6 |
| Molecular Weight | 266.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Piperazine Impurity 64.
As a process- or degradation-related impurity, Piperazine Impurity 64 (CAS 5854-18-2, C13H14O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Piperazine Impurity 64 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 266.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Piperazine Impurity 64 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H14O6 |
| Molecular Weight | 266.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Piperazine Standards
- Piperazine Impurity 56 (CAS 2781850-93-7)
- Piperazine, 1-ethyl-4-(3-methoxy-4-nitrophenyl)- (CAS 761440-34-0)
- Piperazine, 1-[3-chloro-4-(trifluoromethyl)phenyl]- (CAS 888327-52-4)
- 4-Cbz-piperazine-2-carboxylic Acid (CAS 64172-98-1)
- Piperazine Impurity 7 (CAS 1025895-66-2)
- Piperazine Impurity 30 (CAS CATO-C4X-242730)
- 2-(4-Ethyl-piperazine-1-carbonyl)-benzoic acid (CAS 412921-53-0)
- 4-(Piperazine-1-sulfonyl)benzoic acid (CAS 446831-26-1)
Recommended Standards
- Sorbic acid Impurity 6 (CAS CATO-C4X-24236)
- Ataluren Impurity 7 (CAS 775303-92-9)
- Pentoxifylline Impurity 14 (CAS 6493-07-8)
- Pentanal-2,4-dinitrophenylhydrazone (CAS 2057-84-3)
- Istradefylline impurity 35 (CAS CATO-C4X-106135)
- Baloxavir Marboxil Impurity 233 (CAS CATO-C4X-2108233)
- Ethyl Sulbactam Impurity A (CAS CATO-C4X-175635)
- N-[3-Fluoro-4-(morpholin-4-yl)phenyl]-2-(4-methylpiperazin-1-yl)acetamide (CAS 439121-34-3)
- Methyl 5-amino-1-(3-fluorophenyl)-1H-1,2,3-triazole-4-carboxylate (CAS 890093-64-8)
- 3-(benzyloxy)oxetane-3-carboxylic acid (CAS 1888786-93-3)
- 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)benzoic acid (CAS 193151-96-1)
- 2-Chlorobenzo[d]oxazole-7-sulfonamide (CAS 928197-31-3)
- 2-(2-Butoxyethoxy)acetic acid (CAS 82941-26-2)
- Semaglutide impurity 43 (CAS CATO-C4X-222643)
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