5-Chloro-2-methoxybenzyl Bromide CAS 58735-58-3
| CAS No. | 58735-58-3 |
| Molecular Formula | C8H8BrClO |
| Molecular Weight | 235.51 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Chloro-2-methoxybenzyl Bromide is closely related to a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-Chloro-2-methoxybenzyl Bromide (CAS 58735-58-3) is a high-purity analytical reference standard with the molecular formula C8H8BrClO and a molecular weight of 235.51 g/mol.
The molecular framework of 5-Chloro-2-methoxybenzyl Bromide (C8H8BrClO) is characterized by a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8BrClO |
| Molecular Weight | 235.51 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl/Br-containing |
Related Chloro Standards
- 3-Chloro-2-methoxybenzyl bromide (CAS 1044256-94-1)
- 2-Chloro-3-methoxybenzyl bromide (CAS 354138-68-4)
- 2-Chloro-4-(2,4-dichlorophenyl)-1-butene (CAS 951892-55-0)
- 2-Chloro-4-(3,5-dichlorophenyl)-1-butene (CAS 951893-18-8)
- 2-Chloro-1-(2,4-difluoro-5-nitrophenyl)ethanone (CAS 1803827-66-8)
- (5-Chloro-6-(pyrimidin-5-yl)pyridin-3-yl)boronic acid (CAS 2225175-53-9)
- 6-Chloro-2-methyl-4-(trifluoromethyl)-2h-pyrazolo[3,4-b]pyridine (CAS 1018165-10-0)
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Recommended Standards
- 5-Bromo-1-chloro-2-methoxy-3-methylbenzene (CAS 91506-05-7)
- Tulobuterol Impurity 23 (CAS CATO-C4X-213423)
- 4-Bromo-2-chloro-1-ethoxybenzene (CAS 279261-80-2)
- Tulobuterol Impurity 5 (CAS 6314-52-9)
- 10-Dodecen-1-ol, 1-acetate, (10E)- (CAS 35153-09-4)
- 3,5-Dibromo-1-cyclopropyl-1H-1,2,4-triazole (CAS 1240571-23-6)
- 2-Hydroxy-5-((2-methylbenzyl)oxy)benzoic acid (CAS 1413662-21-1)
- Ethyl 4-oxo-2-(trifluoromethyl)cyclohexane-1-carboxylate (CAS 2137936-72-0)
- 3-(2-Bromophenyl)cyclobutan-1-one (CAS 918299-24-8)
- 3-methoxy-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (CAS 1204475-72-8)
- 1-(4-Bromo-2-methylphenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 443636-62-2)
- 2-(2-Bromoethyl)oxirane (CAS 13287-42-8)
- rac Bopindolol-d9 (CAS 1794891-82-9)
- Hepcidin/LEAP-1 (Human); Liver-Expressed Antimicrobial Peptide (CAS 342790-21-0)
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