1-Chloro-2-nitro-4-(trifluoromethoxy)benzene CAS 588-09-0
| CAS No. | 588-09-0 |
| Molecular Formula | C7H3ClF3NO3 |
| Molecular Weight | 241.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Chloro-2-nitro-4-(trifluoromethoxy)benzene.
CATO supplies 1-Chloro-2-nitro-4-(trifluoromethoxy)benzene (CAS 588-09-0), a certified reference material (molecular formula C7H3ClF3NO3, MW 241.55 g/mol) for analytical method development and quality control.
The molecular framework of 1-Chloro-2-nitro-4-(trifluoromethoxy)benzene (C7H3ClF3NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3ClF3NO3 |
| Molecular Weight | 241.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 1-Chloro-2-(difluoromethoxy)-5-fluoro-4-nitrobenzene (CAS 106969-10-2)
- 1-Chloro-4-nitro-2-(trifluoromethoxy)benzene (CAS 113421-97-9)
- 4-CHloro-2-nitro-5-(trifluoromethyl)phenol (CAS 1192021-48-9)
- 4-CHloro-2-nitro-3-(trifluoromethyl)phenol (CAS 1192021-50-3)
- 2-Chloro-5-(trifluoromethoxy)isonicotinic acid (CAS 1221171-77-2)
- 6-Chloro-3-(trifluoromethoxy)picolinic acid (CAS 1221171-83-0)
- 6-Chloro-5-(trifluoromethoxy)picolinic acid (CAS 1221171-90-9)
- 6-Chloro-2-(trifluoromethoxy)nicotinic acid (CAS 1221171-91-0)
Recommended Standards
- 1-(bromomethyl)-3-chloro-5-methoxy-benzene (CAS 885270-32-6)
- 2-(bromomethyl)-1-chloro-4-methoxy-benzene (CAS 3771-13-9)
- 3-Chloro-4-(trifluoromethoxy)nitrobenzene (CAS 158579-81-8)
- 2-Chloro-1-nitro-4-(trifluoromethoxy)benzene (CAS 85578-47-8)
- 4-(2,6,6-Trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzoic acid (CAS 627835-19-2)
- 7,8-Dihydro-5H-pyrano[4,3-b]pyridine-3-carbaldehyde (CAS 1196155-95-9)
- 2-((5-Methyl-1,3,4-thiadiazol-2-yl)thio)-N-(5-methylisoxazol-3(2H)-ylidene)acetamide (CAS 297150-01-7)
- Methyl 6-acetyl-4-chloropicolinate (CAS 135450-69-0)
- 2,3-Difluoro-1,4-bis(trifluoromethyl)benzene (CAS 1099597-67-7)
- Methyl N-phenyl-N-(phenylsulfonyl)glycinate (CAS 92851-64-4)
- trans-4-((Dimethylamino)methyl)cyclohexanamine diacetate (CAS 1356953-44-0)
- 3-Bromo-4-(1-pyrazolyl)benzoic Acid (CAS 1186663-57-9)
- 2-(Cyclopropanecarboxamido)-5-iodobenzoic acid (CAS 433966-91-7)
- D-β-Asp9-Tirzepatide (CAS CATO-CPTD788932)
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