Nicardipine EP Impurity A (Dehydro Nicardipine) CAS 59875-58-0
| CAS No. | 59875-58-0 |
| Molecular Formula | C26H27N3O6 |
| Molecular Weight | 477.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nicardipine EP Impurity A (Dehydro Nicardipine).
As a process- or degradation-related impurity, Nicardipine EP Impurity A (Dehydro Nicardipine) (CAS 59875-58-0, C26H27N3O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Nicardipine EP Impurity A (Dehydro Nicardipine) (C26H27N3O6) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 477.51 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nicardipine EP Impurity A (Dehydro Nicardipine) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H27N3O6 |
| Molecular Weight | 477.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Nitrogen Atoms | 3 |
Related Nicardipine Standards
- (S)-Nicardipine HCl (CAS 118934-78-4)
- Nicardipine (CAS 55985-32-5)
- (R)-(+)-Nicardipine (CAS 76093-35-1)
- (S)-(-)-Nicardipine (CAS 76093-36-2)
- Nicardipine O-Desmethyl (CAS 123973-71-7)
- Nicardipine Impurity 57 (CAS CATO-C4X-171057)
- Nicardipine Impurity 30 (CAS CATO-C4X-171030)
- Nicardipine Impurity 58 (CAS CATO-C4X-171058)
Recommended Standards
- Cefminox Impurity 28 (CAS CATO-C4X-192628)
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- Fmoc-D-His(Boc)-OH (CAS 159631-28-4)
- Cetirizine EP Impurity E(Dihydrochloride) (CAS 83881-56-5)
- Pimavanserin Impurity 41 (CAS CATO-C4X-193841)
- Tenofovir disoproxil Impurity 130 (CAS CATO-C4X-1076130)
- 2,5-Dibromo-3-methylfuran (CAS 89284-16-2)
- (4R,4'R)-1,1'-Bis(3-(tert-butyl)phenyl)-4,4'-dicyclohexyl-4,4',5,5'-tetrahydro-1H,1'H-2,2'-biimidazole (CAS 2770054-34-5)
- 3-Benzyl-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (CAS 1144040-56-1)
- Ethyl 4-amino-3-methylbutanoate (CAS 336191-10-7)
- (3-Cyclohexyl-5-(trifluoromethyl)phenyl)boronic acid (CAS 2225169-61-7)
- Methyl 2-(2-chloro-6-ethoxy-4-formylphenoxy)propanoate (CAS 879178-35-5)
- Acetyl Tripeptide-1 (CAS 350595-76-5)
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