Promethazine EP Impurity C HCl CAS 60113-77-1
| CAS No. | 60113-77-1 |
| Molecular Formula | C16H18N2S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Promethazine EP Impurity C HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Promethazine EP Impurity C HCl (CAS 60113-77-1) is a certified pharmaceutical impurity reference standard with the molecular formula C16H18N2SHCl and a molecular weight of 306.85 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution, Promethazine EP Impurity C HCl is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 306.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H18N2S HCl |
| Molecular Weight | 306.85 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Promethazine Standards
- Promethazine Impurity 24 (CAS 1070758-14-3)
- Promethazine Impurity 5 (CAS 108-14-5)
- Promethazine Impurity 11 (CAS 108-16-7)
- Promethazine Sulfoxide N-Oxide HCl (CAS 1135334-50-7)
- Promethazine-D4 Hydrochloride (CAS 1173018-74-0)
- Promethazine Sulfoxide-d6 (CAS 1189892-93-0)
- Promethazine-d6 Hydrochloride (CAS 1189947-02-1)
- Promethazine Impurity 27 (CAS 1209-66-1)
Recommended Standards
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- Carbomethoxyethylthioethyl 4-O-(4-O-[6-O-{a-D-glucopyranosyl}-a-D-glucopyranosyl]-a-D-glucopyranosyl)-b-D-glucopyranoside (CAS 90214-99-6)
- 4-Bromo-N-(3-nitrophenyl)benzamide (CAS 349125-23-1)
- (S)-2-Amino-N,3-dimethyl-N-((S)-1-methylpyrrolidin-3-yl)butanamide (CAS 1401665-36-8)
- 3′-(trifluoromethyl)propiophenone (CAS 1533-03-5)
- Pent-4-yn-1-yl 4-methylbenzenesulfonate (CAS 77758-50-0)
- Acetyl-Exenatide trifluoroacetate salt (CAS 305815-28-5)
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