Prostaglandin Impurity 27 CAS 60203-57-8
| CAS No. | 60203-57-8 |
| Molecular Formula | C20H30O4 |
| Molecular Weight | 334.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Prostaglandin Impurity 27 (CAS 60203-57-8, C20H30O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Prostaglandin Impurity 27 (C20H30O4) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H30O4 |
| Molecular Weight | 334.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
Related Prostaglandin Standards
- Δ-12 Prostaglandin J2 (CAS 87893-54-7)
- 15-epi Prostaglandin A1 (CAS 20897-92-1)
- Prostaglandin F2α 1,15-lactone (CAS 55314-49-3)
- Prostaglandin F2α; 1,11-lactone (CAS 62410-84-8)
- Prostaglandin A₂-d₄ (CAS 201608-18-6)
- Prostaglandin E1 Alcohol (CAS 21562-57-2)
- Prostaglandin Impurity 3 (CAS 64700-71-6)
- Prostaglandin Impurity 1 (CAS 240405-20-3)
Recommended Standards
- Dinoprostone EP Impurity E (CAS 13367-85-6)
- Dinoprostone EP Impurity D (CAS 13345-50-1)
- 5,6-Dihydro-5,6-Dihydroxy Retinoic Acid (CAS 73341-58-9)
- Ebastine Impurity 9 (CAS 632-50-8)
- Olsalazine EP Impurity C (CAS 259151-72-9)
- Canagliflozin Impurity 36 (CAS CATO-C4X-112336)
- Methotrexate Impurity 73 (CAS CATO-C4X-115473)
- 2,3-Dichloro-5-methylpyrazine (CAS 32493-78-0)
- 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1h-pyrrolo[2,3-b]pyridine (CAS 281658-42-2)
- 1-(1-Methylcyclopropyl)-1H-pyrazole-3-carboxylic acid (CAS 2468058-14-0)
- (S)-1-(4-Isobutylphenyl)ethan-1-ol (CAS 125653-66-9)
- 2,4,6-Tris(3-fluoro-4-methoxyphenyl)-1,3,5,2,4,6-trioxatriborinane (CAS 149506-26-3)
- 3-Chloro-2-hydroxy-4-methoxybenzaldehyde (CAS 72482-15-6)
- ([D?]Val?·1?)-C-Peptide (human) (CAS 1802078-41-6)
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