2-chloro-1,8-naphthyridine-3-carbonitrile CAS 60467-75-6
| CAS No. | 60467-75-6 |
| Molecular Formula | C9H4ClN3 |
| Molecular Weight | 189.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-chloro-1,8-naphthyridine-3-carbonitrile (CAS 60467-75-6), molecular formula C9H4ClN3 and molecular weight 189.60 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C9H4ClN3, 2-chloro-1,8-naphthyridine-3-carbonitrile contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 189.60 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H4ClN3 |
| Molecular Weight | 189.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
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- 3-(5-Chloro-3-methyl-1,2-oxazol-4-yl)propanoic acid (CAS 1209765-87-6)
- 4-Chloro-1,8-naphthyridine-3-carbonitrile (CAS 1234616-73-9)
- Methyl 2-(5-chloro-3-methyl-1,2-oxazol-4-yl)acetate (CAS 1239772-79-2)
- 6-chloro-1,7-naphthyridine-5-carbonitrile (CAS 1256463-74-7)
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Recommended Standards
- 2-chloro-1,6-naphthyridine-7-carbonitrile (CAS 2677885-76-4)
- 2-Chloro-4,6-dimethoxypyrimidin-5-amine (CAS 444151-94-4)
- 2-chloro-1,6-naphthyridine-3-carbonitrile (CAS 50345-85-2)
- 3-Chloroquinoxaline-2-carbonitrile (CAS 40254-89-5)
- 5-methyl-1H-1,3-benzodiazole-2-carbaldehyde hydrochloride (CAS 1185304-18-0)
- 2-Amino-4,5-dimethyl-1-(o-tolyl)-1H-pyrrole-3-carbonitrile (CAS 72578-52-0)
- (S)-2-Amino-N-(3-chloro-benzyl)-3-methyl-butyramide (CAS 1175683-62-1)
- 4-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}-2-(phenylsulfonyl)phenyl 4-methoxybenzenesulfonate (CAS 306979-62-4)
- N-((1R,2R)-1-Hydroxy-1-((4R,5R)-5-hydroxy-2-phenyl-1,3-dioxan-4-yl)-3-oxopropan-2-yl)acetamide (CAS 420118-03-2)
- 3-Methoxy-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 2246810-37-5)
- Dup-714 (CAS 130982-43-3)
- (2S,3S)-2-((S)-2-Amino-3-(1H-imidazol-4-yl)propanamido)-3-methylpentanoic acid (CAS 129050-48-2)
- 4-(Diisobutylamino)butan-1-ol (CAS 70289-33-7)
- Semaglutide Impurity 128 (CAS 2490269-78-6)
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